Hepatitis B Virus
Hepatitis B virus causes both acute and chronic liver infections in man. An unusual feature
is the prolonged viraemia, lasting for up to several months in acute infections
and for many years (even for life) in chronic infections.
A diagrammatic representation of the hepatitis B virion and the surface antigen
Virions are 42nm in diameter and possess an isometric nucleocapsid or "core" of 27nm
in diameter, surrounded by an outer coat approximately 4nm thick.
The protein of the virion coat is termed "surface antigen" or HBsAg. It is sometimes
extended as a tubular tail on one side of the virus particle. The surface antigen
is generally produced in vast excess, and is found in the blood of infected individuals
in the form of filamentous and spherical particles. Filamentous particles are identical to the
virion "tails" - they vary in length and have a mean diameter of about 22nm. They sometimes
display regular, non-helical transverse striations.
Core particles: The actual number and arrangement of the capsomers has not been
established with certainty,
but certain images suggest a lattice formation, as shown below.
A group of hepatitis B virions (right) and enlargements of the two
exposed cores (indicated by arrows).
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© Copyright Linda M Stannard, 1995.