All herpesviruses replicate in the nucleus of the cell. An accumulation of
viral proteins results in the formation of characteristic eosinophilic
Minor differences in CPE allow distinction between the different types of herpesvirus.
Human cytomegalovirus replicates only in fibroblast cells (not in epithelial
The virus is slow-growing and thus foci are small and discrete. Characteristic eosinophilic "owl-eye" inclusions are evident in the nuclei of infected cells.
Varicella zoster virus
Varicella zoster virus will replicate
in either epithelial cells (as shown here) or fibroblasts.
CPE takes much longer to become apparent than with HSV.
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