Research

The Division has an active research programme, which has three broad focus areas. Firstly, we conduct research around the development, evaluation and implementation of novel diagnostic tests for tuberculosis. Secondly, we host a satellite unit of the National Institute for Communicable Diseases, which focuses on the molecular epidemiology of drug-resistant nosocomial pathogens. Thirdly, we have a new interest in understanding the dynamics of the nasopharyngeal microbiome, and its relationship to childhood pneumonia and asthma. By adopting a research strategy that is based on investigating specific aspects of the physiology and metabolism of M. tuberculosis, the Molecular Mycobacteriology Research Unit (MMRU) has positioned itself at the front-end of TB drug discovery research

 

Principal Investigators

 

Scientific Advisors

 

Visiting Scientists

Dr. Adebayo Osagie Shittu
BSc (Hons) (OAU, Ile-Ife); MSc (OAU, Ile-Ife); PhD (UKZN, SA)

email:
tel: 021 406 6727

University website

 

Current Students
Name Degree Topics Supervisors
Veronica Allen PhD The Development and Evaluation of Novel Diagnostic Tests for TB. Prof Mark Nicol
Dr Lemese Ah Tow Edries
Mischka Moodley PhD Investigation of novel TB diagnostics as point-of-care tests in low-income settings. Prof Mark Nicol
Reggie Mutetwa PhD Preventing adverse outcomes in smear negative TB suspects in the era of collaborative TB and HIV programmes: the contribution of new TB diagnostics. Prof Mark Nicol
Dr Elizabeth Corbett (LSHTM)
Prof Peter Mason (BRTI, Harare)
Rajesh Sarkar PhD The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on the host population.

An evaluation of a novel culture supplement to improve Mycobacterium tuberculosis growth in clinical specimens.
Prof Mark Nicol
Prof Robert Wilkinson
Babu Muhamed MSc The molecular epidemiology of Streptococcus pyogenes pharyngitis among children in the Vanguard Community (Bonteheuwel/Langa), Cape Town, South Africa. Dr Andrew Whitelaw
Dr Mark Engel
Prof Bongani Mayosi
Shima Mohammed MSc Investigation of the genetic background of Staphylococcus aureus in the nasopharyngeal microbiome. Prof Mark Nicol
Dr Eliya Madikane
Felix Dube MSc Molecular epidemiology of nasopharyngeal carriage of Streptococcus pneumoniae in children less than 2 years of age from the Cape Winelands: Implications for vaccine strategies. Prof Mark Nicol
Dr Mamadou Kaba
Malefu Moleleki MSc An investigation into the genetic background of some methicillin-susceptible S. aureus isolates from Cape Town hospitals. Prof Gay Elisha
Dr Colleen Bamford
Geoffrey Chipungu MMed Characterization of community acquired extended spectrum beta-lactamase producing Klebsiella pneumoniae and Escherichia coli isolated from patients attending UCT teaching hospitals. Dr Andrew Whitelaw
Mischka Moodley MMed Acinetobacter baumanniii: an evaluation of five susceptibility test methods to detect tobramycin resistance in an epidemiologically related cluster. Dr Stephen Oliver
Prof Gay Elisha
Nicolette Rivera MMed Validation of a Panfungal PCR Assay for Detection and Identification of Fungi from Tissue Samples. Dr Colleen Bamford
Justyna Wojno MMed Serum bactericidal activity of colistin against Acinetobacter baumannii in patients with normal versus impaired renal function. Dr Stephen Oliver