Research
The Division has an active research programme, which has three broad focus areas. Firstly, we conduct research around the development, evaluation and implementation of novel diagnostic tests for tuberculosis. Secondly, we host a satellite unit of the National Institute for Communicable Diseases, which focuses on the molecular epidemiology of drug-resistant nosocomial pathogens. Thirdly, we have a new interest in understanding the dynamics of the nasopharyngeal microbiome, and its relationship to childhood pneumonia and asthma. By adopting a research strategy that is based on investigating specific aspects of the physiology and metabolism of M. tuberculosis, the Molecular Mycobacteriology Research Unit (MMRU) has positioned itself at the front-end of TB drug discovery research
Principal Investigators
- Mark Nicol
- Valerie Mizrahi
- Gregory Hussey
- Colleen Bamford
- Andrew Whitelaw
- Digby Warner
- Eliya Madikane
Scientific Advisors
Visiting Scientists
Dr. Adebayo Osagie Shittu
BSc (Hons) (OAU, Ile-Ife); MSc (OAU, Ile-Ife); PhD (UKZN, SA)
email:
tel: 021 406 6727
University website
Current Students
| Name | Degree | Topics | Supervisors |
| Veronica Allen | PhD | The Development and Evaluation of Novel Diagnostic Tests for TB. | Prof Mark Nicol Dr Lemese Ah Tow Edries |
| Mischka Moodley | PhD | Investigation of novel TB diagnostics as point-of-care tests in low-income settings. | Prof Mark Nicol |
| Reggie Mutetwa | PhD | Preventing adverse outcomes in smear negative TB suspects in the era of collaborative TB and HIV programmes: the contribution of new TB diagnostics. | Prof Mark Nicol Dr Elizabeth Corbett (LSHTM) Prof Peter Mason (BRTI, Harare) |
| Rajesh Sarkar | PhD | The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on the host population. An evaluation of a novel culture supplement to improve Mycobacterium tuberculosis growth in clinical specimens. |
Prof Mark Nicol Prof Robert Wilkinson |
| Babu Muhamed | MSc | The molecular epidemiology of Streptococcus pyogenes pharyngitis among children in the Vanguard Community (Bonteheuwel/Langa), Cape Town, South Africa. | Dr Andrew Whitelaw Dr Mark Engel Prof Bongani Mayosi |
| Shima Mohammed | MSc | Investigation of the genetic background of Staphylococcus aureus in the nasopharyngeal microbiome. | Prof Mark Nicol Dr Eliya Madikane |
| Felix Dube | MSc | Molecular epidemiology of nasopharyngeal carriage of Streptococcus pneumoniae in children less than 2 years of age from the Cape Winelands: Implications for vaccine strategies. | Prof Mark Nicol Dr Mamadou Kaba |
| Malefu Moleleki | MSc | An investigation into the genetic background of some methicillin-susceptible S. aureus isolates from Cape Town hospitals. | Prof Gay Elisha Dr Colleen Bamford |
| Geoffrey Chipungu | MMed | Characterization of community acquired extended spectrum beta-lactamase producing Klebsiella pneumoniae and Escherichia coli isolated from patients attending UCT teaching hospitals. | Dr Andrew Whitelaw |
| Mischka Moodley | MMed | Acinetobacter baumanniii: an evaluation of five susceptibility test methods to detect tobramycin resistance in an epidemiologically related cluster. | Dr Stephen Oliver Prof Gay Elisha |
| Nicolette Rivera | MMed | Validation of a Panfungal PCR Assay for Detection and Identification of Fungi from Tissue Samples. | Dr Colleen Bamford |
| Justyna Wojno | MMed | Serum bactericidal activity of colistin against Acinetobacter baumannii in patients with normal versus impaired renal function. | Dr Stephen Oliver |
