Publications 2009 - 2010

  • Nicol MP. New developments in the laboratory diagnosis of tuberculosis.
    Continuing Medical Education. 2010 June
  • Connell TG, Davies MA, Johannisen C, Wood K, Pienaar S, Wilkinson KA, Wilkinson RJ, Zar HJ, Beatty D, Nicol MP, Curtis N, Eley B. Reversion and conversion of M. tuberculosis IFN-γ ELISpot results during anti-tuberculous treatment in HIV-infected children.
    BMC Infect. Dis. 2010, 10:138.
  • Helen S.Cox, Cheryl McDermid, Virginia Azevedo, Odelia Muller, David Coetzee, John Simpson, Marinus Barnard, Gerrit Coetzee, Gilles van Cutsem, Eric Goemaere. Epidemic Levels of Drug Resistant Tuberculosis ( MDR and XDR-TB) in a High HIV Prevalence Setting in Khayelitsha, South Africa.
    PLoS ONE November 2010 Vol5 Issue 11 e13901
  • Zar HJ, Connell T, Nicol MP. Diagnosis of pulmonary tuberculosis in children: new advances.
    Expert Rev. Anti Infect. Ther. 2010 8(3), 277-288
  • Nicol MP, Grobler LA. MVA-85A, a novel candidate booster vaccine for the prevention of tuberculosis in children and adults.
    Curr Opin Mol Ther. 2010 Feb;12(1):124-34.
  • Wright CA, Bamford C, Prince Y, Vermaak A, Hoek KG, Marais BJ, Warren RM. Mycobacterial Transport medium for Fine Needle Aspiration Biopsies.
    Archives of Disease in Childhood 2010; 95:48-50.
  • D. Sissolak, C. Bamford, S. Mehtar. The potential to transmit Mycobacterium tuberculosis at a South African tertiary teaching hospital.
    Int J Infect Dis 2010;5:e423-e428.
  • Bamford CM, Taljaard J. Potential for nosocomial transmission of multi-drug resistant (MDR) tuberculosis in a South African tertiary hospital.
    S Afr Med J 2010;100:438-441.
  • Bamford CM, Goodway J, Hoffmann, R. Rapid identification and susceptibility testing of gram-negative bacilli from blood cultures using Vitek 2 system.
    South African Journal of Epidemiology and Infection 2010;25:28 -31.
  • Morrow BM, Hsaio NY, Zampoli M, Whitelaw A, Zar HJ. Pneumocystis Pneumonia in South African Children With and Without Human Immunodeficiency Virus Infection in the Era of Highly Active Antiretroviral Therapy.
    Pediatr Infect Dis J. 2010 Jan 12
  • Khutlang R, Krishnan S, Whitelaw A, Douglas TS. Automated detection of tuberculosis in Ziehl-Neelsen-stained sputum smears using two one-class classifiers.
    J Microsc. 2010 Jan;237(1):96-102.
  • Morrow BM, Whitelaw A, Zampoli M, Westwood AT (2010) Infection Control in Cystic Fibrosis: Recommendations for South African hospitals, clinics and social settings.
    South African Respiratory Journal. 16 (1): 20 - 25.
  • Dheda K, Davids V, Lenders L, Roberts T, Meldau R, Ling D, Brunet L, van Zyl Smit R, Peter J, Green C, Badri M, Sechi L, Sharma S, Hoelscher M, Dawson R, Whitelaw A, Blackburn J, Pai M, Zumla A. Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samples.
    PLoS One. 2010 Mar 24;5(3):e9848.
  • Hanekom WA, Lawn SD, Dheda K, Whitelaw A.Tuberculosis research update.
    Trop Med Int Health. 2010 Aug;15(8):981-9.
  • Jansen van Rensburg MJ, Eliya Madikane V, Whitelaw A, Chachage M, Haffejee S, Gay Elisha B. The dominant methicillin-resistant Staphylococcus aureus clone from hospitals in Cape Town has an unusual genotype: ST612.
    Clin Microbiol Infect. 2010 Sep 20.
  • Middelkoop K, Bekker LG, Myer L, Whitelaw A, Grant A, Kaplan G, McIntyre J, Wood R.
    Antiretroviral program associated with reduction in untreated prevalent tuberculosis in a South African township.
    Am J Respir Crit Care Med. 2010 Oct 15;182(8):1080-5
  • Evans J, Segal H. Novel multiplex allele-specific PCR assays for the detection of resistance to second-line drugs in Mycobacterium tuberculosis.
    J Antimicrob Chemother. 2010 May;65(5):897-900. Epub 2010 Feb 25.
  • D'Souza DTB, Mistry NF, Vira TS, Dholakia Y, Hoffner S, Pasvol G, Nicol M, Wilkinson RJ. High levels of Multidrug Resistant Tuberculosis in new and treatment-failure patients from the Revised National Tuberculosis Control Programme in an Urban metropolis (Mumbai) in Western India.
    BMC Public Health. 2009 Jun 29;9:211
  • Davies MA, Connell T, Johannisen C, Wood K, Pienaar S, Wilkinson KA, Wilkinson RJ, Zar HJ, Eley B, Beatty D, Curtis N and Nicol MP. Detection of tuberculosis in HIV-infected children using an enzyme-linked immunospot assay.
    AIDS. 2009 May 15;23(8):961-9.
  • Evans J, Stead M, Nicol, MP, Segal H. Rapid Genotypic Assays to Identify Drug-Resistant Mycobacterium tuberculosis in South Africa.
    J Antimicrob Chemother. 2009 Jan;63(1):11-6.
  • Nicol MP, Davies MA, Wood K, Hatherill M, Workman L, Hawkridge A, Eley B, Wilkinson K, Wilkinson RJ, Hanekom WA, Beatty D, Hussey D. A comparison of T-SPOT.TB and tuberculin skin test for the evaluation of young children at high risk for tuberculosis in a community setting.
    Pediatrics. 2009 Jan;123(1):38-43.
  • Gounden R, Bamford C, van Zyl-Smit R, Cohen K, Maartens G. Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections.
    BMC Infect.Dis. 2009 Mar 9;9:26.
  • Wright CA, Hesseling AC, Bamford C, Burgess S, Warren R, Marais BJ. Fine needle aspiration biopsy - a first line diagnostic procedure in pediatric tuberculosis suspects with peripheral lymphadenopathy?
    Int J Tuberc Lung Dis. 2009; 13:1373-1379.
  • Hatherill M, Hawkridge T, Zar H, Whitelaw A, Tameris M, Workman L, Geiter L, Hanekom W, Hussey G. Induced sputum or gastric lavage for community-based diagnosis of childhood pulmonary tuberculosis?
    Arch Dis Child 2009; 94: 195-201.
  • Hesseling AC, Cotton MF, Jennings T, Whitelaw A, Johnson LF, Eley B, Roux P, Godfrey-Faussett P, Schaaf HS. High incidence of tuberculosis among HIV-infected infants: evidence from a South African population-based study highlights the need for improved tuberculosis control strategies.
    Clin Infect Dis 2009; 48: 108-114
  • Dheda K, Van-Zyl Smit RN, Sechi LA, Badri M, Meldau R, Symons G, Khalfey H, Carr I, Maredza A, Dawson R, Wainright H, Whitelaw A, Bateman E, Zumla A. (2009) Clinical diagnostic utility of IP-10 and LAM antigen levels for the diagnosis of tuberculous pleural effusions in a high burden setting.
    PLoS ONE 4(3): e4689. doi:10.1371/journal.pone.0004689
  • Dheda K, van Zyl-Smit RN, Sechi LA, Badri M, Meldau R, Meldau S, Symons G, Semple L, Maredza A, Dawson R, Wainright H, Whitelaw A, Vallie Y, Raubenheimer P, Bateman ED, Zumla A..Utility of quantitative T cell responses versus unstimulated IFN-{gamma} for the diagnosis of pleural tuberculosis. 
    Eur Respir J. 2009 Apr 22
  • Dheda K, van Zyl-Smit RN, Meldau R, Meldau S, Symons G, Khalfey H, Govender N, Rosu V, Sechi LA, Maredza A, Semple PL, Whitelaw A, Wainright H, Badri M, Dawson R, Bateman ED, Zumla A. Quantitative lung T cell responses aid the rapid diagnosis of pulmonary tuberculosis. 
    Thorax. 2009 Jul 9.
  • Hesseling AC, Johnson LF, Jaspan H, Cotton MF, Whitelaw A, Schaaf HS, Fine PEM, Eley BS, Marais BJ, Nuttall J, N Beyers, Godfrey-Faussett P. Disseminated bacille Calmette-GuĂ©rin disease in HIV-infected South African infants.
    Bull WHO 2009;87:505-51
  • Middelkoop K, Bekker L, Mathema B, Shashkina E, Kurepina N, Whitelaw A, Fallows D, Morrow C, Kreiswirth B, Kaplan G, Wood R. Molecular Epidemiology of Mycobacterium tuberculosis in a South African Community with High HIV Prevalence.
    J Infect Dis 2009; 200:1207-11
  • Evans J, Stead MC, Nicol MP, Segal H. Rapid genotypic assays to identify drug-resistant Mycobacterium tuberculosis in South Africa.
    J Antimicrob Chemother. 2009 Jan;63(1):11-6. Epub 2008 Oct 21.