Peter Meissner

1. Pandie M; Sonderup M, Meissner PN, Mendelson M.
   Acute porphyria precipitated by nevirapine.
   AIDS, 2010 24(16): 2597 - 2599
2. Corrigall AV, Campbell JAH, Siziba K, Kirsch RE, Meissner PN.
   The Expression of Protoporphyrinogen Oxidase in human tissues.
   Cellular and Molecular Biology, 2009, 55(2): 89 - 95

 

Jonathan Blackburn

1. Dheda J, Davids V, Lenders L, Roberts T, Meldau R, Ling D, Brunet L, Van Zyl Smit R, Peter J, Green C, Badri M, Sechi L, Sharma S, Hoelscher M, Dawson R, Whitelaw A, Blackburn J, Pai M, Zumla A.
   Clinical Utility of a Commercial LAM-ELISA Assay for TB Diagnosis in HIV-Infected Patients Using Urine and Sputum Samples.
   PLoS ONE, 2010, 5(3): e9848 1 - 8
2. Zawaira A, Gallotta M, Beeton-Kempen N, Coulson L, Marais P, Kuttel M, Blackburn J. .
   Exhaustive computational search of ionic-charge clusters that mediate interactions between mammalian cytochrome P450 (CYP) and P450-oxidoreductase (POR) proteins.
   Computational Biology and Chemistry, 2010, 34: 42 - 52.
3. Blackburn, JM, Serufuri JMS, Kumuthini J.
   An invitro method of diagnosis of cancer. - NOT ACCREDITED
   
   Patent Application Number: 2009/05150
   
   
4. Hiller R, Blackburn JM.
   Integrating high throughput technologies to advance genomic and proteomic research in South Africa.
   Biotechnol J. 2008 Nov;3(11):1351-4.
5. Dakshinamurthy AG, Ramesar R, Goldberg P, Blackburn JM.
   Infrequent and low expression of cancer-testis antigens located on the X chromosome in colorectal cancer: implications for immunotherapy in South African populations.
   Biotechnol J. 2008 Nov;3(11):1417-23.
6. Zhi ZL, Laurent N, Powell AK, Karamanska R, Fais M, Voglmeir J, Wright A, Blackburn JM, Crocker PR, Russell DA, Flitsch S, Field RA, Turnbull JE.
   A versatile gold surface approach for fabrication and interrogation of glycoarrays.
   Chembiochem. 2008 Jul 2;9(10):1568-75.
7. Jonathan Blackburn, Natasha Beeton-Kempen, Aubrey Shoko
   Personalizing protein-drug interactions
   Pure Appl.chem, Vol 80, No 8 pp 1811-1820, 2008
8. Laurent N, Voglmeir J, Wright A, Blackburn J, Pham NT, Wong SC, Gaskell SJ, Flitsch SL. Enzymatic glycosylation of peptide arrays on gold surfaces.
   Chembiochem. 2008 Apr 14;9(6):883-7.

 

Arieh Katz

1. Abera AB, Sales KJ, Catalano RD, Katz AA, Jabbour HN.
   EP2 receptor mediated cAMP release is augmented by PGF2a activation of the FP receptor via the calcium-calmodulin pathway.
   Cellular Signalling, 2010, 22: 71 - 79.
2. Folefoc AT, Fromme BJ, Katz AA, Flanagan CA.
   South African Mutations of the CCR5 Coreceptor for HIV Modify Interaction With Chemokines and HIV Envelope Protein.
   Journal of Acquired Immune Deficiency Syndromes, 2010, 54(4): 352 - 359.
3. Minsaas L, Planagumà J, Madziva M, Krakstad BF, Masià-Balagué M, Katz AA, Aragay AM.
   Filamin A Binds to CCR2B and Regulates Its Internalization.
   PLoS ONE, 2010, 5(8): e12212 1 - 14.
4. Stewart AJ, Katz AA, Millar RP, Morgan K.
   Retention and Silencing of Prepro-GnRH-II and Type II GnRH Receptor Genes in Mammals.
   Neuroendocrinology, 2009, 90: 416 - 432
5. Fromme BJ, Coetsee M, Van Der Watt P, Chan MC, Sperling KM, Katz AA, Flanagan CA.
   High-affinity binding of southern African HIV type 1 subtype C envelope protein, gp120, to the CCR5 coreceptor.
   AIDS Res Hum Retroviruses. 2008 Dec;24(12):1527-36.

 

Edward Sturrock

1. Dimitropoulos N, Papakyriakou A, Dalkas GA, Sturrock ED, Spyroulias GA.
   A Computational Approach to the Study of the Binding Mode of Dual ACE/NEP Inbibitors.
   Journal of Chemical Information and Modelling, 2010, 50: 388 - 396
2. The N Domain of Human Angiotensin-I-converting Enzyme. The Role of N-Glycosylation and the Crystal Structure in Complex with an N Domain-Specific Phosphinic Inbibitor RXP407
   Journal of Biological Chemistry, 2010, 285(46): 35685 - 35693.
3. Akif M, Ntai I, Sturrock ED, Isaac RE, Bachmann BO, Acharya KR.
   Crystal structure of a phosphonotripeptide K-26 in complex with angiotensin converting enzyme homologue (AnCE) from Drosophila melanogaster.
   Biochemical and Biophysical Research Communications, 2010, 398: 532 - 536.
4. Akif M, Georgiadis D, Mahajan A, Dive V, Sturrock ED, Isaac RE, Acharya KR.
   High-Resolution Crystal Structures of Drosophila melanogaster Angiotensin-Converting Enzyme in Complex with Novel Inhibitors and Antihypertensive Drugs.
   Journal of Molecular Biology; 2010, 400: 502 - 517.
5. de Andrade MCC, Affonso R, Fernandes FB, Febba AC, de Silva IDCG, Stella RCR, Marson O, Jubilut GN, Hirata IY, Carmona AK, Corradi H, Acharya KR, Sturrock ED, Casarini DE.
   Spectroscopic and structural analysis of somatic and N-domain angiotensin I-converting enzyme isoforms from mesangial cells from Wistar and spontaneously hypertensive rats.
   International Journal of Biological Macromolecules, 2010, 47: 238 - 243.
6. Watermeyer JM, Kröger WL, O’Neill HG, Sewell BT, Sturrock ED.
   Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril.
   Biochemical Journal, 2010, 428: 67 - 74.
7. Kröger WL, Douglas RG, O'Neill HG, Dive V, Sturrock ED.
   Investigating the Domain Specificity of Phosphinic Inhibitors RXPA380 and RXP407 in Angiotensin-Converting Enzyme
   Biochemistry, 2009, 48: 8405 - 8412
8. Cunha CEL,de Fátima Magliarelli H, Paschoalin T, Nchinda AT, Lima JC, Juliano MA, Paiva PB, Sturrock ED, Travassos LR, Carmona AK.
   Catalytic properties of recombinant dipeptidyl carboxypeptidase from Escherichia coli: a comparative study with angiotensin I-converting enzyme.
   Biological Chemistry, 2009 September online; 390(09): 931 - 940
9. Dive V, Chang CF, Yiotakis A, Sturrock ED.
   Inhibition of Zinc Metallopeptidases in Cardiovascular Disease - From Unity to Trinity, or Duality?
   Current Pharmaceutical Design, 2009, 15: 3606 - 3621
10. Watermeyer JM, Kröger WL, Sturrock ED, Ethlers MRW.
    Angiotensin-Converting Enzyme - New Insights into Structure, Biological Significance and Prospects for Domain-Selective Inhibitors
    Current Enzyme Inhibition, 2009, 5(3): 134 - 147 - NOT ACCREDITED
11. Gordon K, Balyasnikova IV, Nesterovitch AB, Schwartz DE, Sturrock ED, Danilov SM.
    Fine epitoe mapping of monoclonal antibodies 9B9 and 3G8 to the N domain of angiotensin-converting enzyme (CD143) defines a region involved in regulating angiotensin-converting enzyme dimerization and shedding.
    Tissue Antigens, 2009, 75: 136 - 150.
12. O'Neill HG, Redelinghuys P, Schwager SL, Sturrock ED.
    The role of glycosylation and domain interactions in the thermal stability of human angiotensin-converting enzyme.
    Biol Chem. 2008 Sep;389(9):1153 - 61.
13. Naperova IA, Balyasnikova IV, Schwartz DE, Watermeyer J, Sturrock ED, Kost OA, Danilov SM.
    Mapping of conformational mAb epitopes to the C domain of human angiotensin I-converting enzyme.
    J Proteome Res. 2008 Aug;7(8):3396-411. Epub 2008 Jun 25.
14. Epitope mapping of mAbs to denatured human testicular ACE (CD143).
    Balyasnikova IV, Metzger R, Franke FE, Conrad N, Towbin H, Schwartz DE, Sturrock ED, Danilov SM.
    Tissue Antigens. 2008 Oct;72(4):354-68. Epub 2008 Aug 12.
15. Watermeyer JM, Kröger WL, O'Neill HG, Sewell BT, Sturrock ED.
    Probing the basis of domain-dependent inhibition using novel ketone inhibitors of Angiotensin-converting enzyme.Biochemistry. 2008 Jun 3;47(22):5942-50. Epub 2008 May 6.

 

Robert (Bob) Millar

1. Millar RP, Roseweir AK, Tello JA, Anderson RA, George JT, Morgan K, Pawson AJ.
   Kisspeptin antagonists: Unraveling the role of kisspeptin in reproductive physiology.
   Brain Research 1364, 2010, 81 - 89.
2. Teixeira L, Guimiot F, Dodé C, Fallet-Bianco C, Millar RP, Delezoide AL, Hardelin JP.
   Defective migration of neuroendocrine GnRH cells in human arrhinencephalic conditions.
   The Journal of Clinical Investigation, 2010, 120(10): 3668 - 3672.
3. Ramaesh T, Logie JJ, Roseweir AK, Millar RP, Walker BR, Hadoke PWF, Reynolds RM.
   Kisspeptin-10 Inhibits Angiogenesis in Human Placental Vessels ex Vivo and Endothelial Cells in Vitro.
   Endocrinology, 2010, 151(12): 5927 - 5934.
4. Millar RP, Newton CL.
   The Year in G Protein-Coupled Receptor Research.
   Molecular Endocrinology, 2010, 24(1): 261 - 274.
5. George JT, Millar RP, Anderson RA.
   Hypothesis: Kisspeptin Mediates Male Hypogonadism in Obesity and Type 2 Diabetes.
   Neuroendocrinology, 2010, 91: 302 - 307.
6. Ukuba T, Morgan K, Pawson AJ, Osugi T, Chowdhury VS, Minakata H, Tsutsui K, Millar RP, Bentley GE.
   Identification of Human GnIH Homologs, RFRP-1 and RFRP-3, and the Cognate Receptor, GPR147 in the human Hypothalmic Pituitary Axis.
   PLoS ONE, 2009, 4(12): e8400 1 - 7.
7. Li XF, Kinsey-Jones JS, Cheng Y, Knox AMI, Lin Y, Petrou NA, Roseweir AK, Lightman SL, Milligan SR, Millar RP, O'Byrne KT.
   Kisspeptin Signalling in the Hypothalamic Arcuate Nucleus Regulates GnRH Pulse Generator Frequency in the Rat
   PLoS ONE, 2009, 4(12): e8334 1 - 9
8. Joseph NT, Morgan K, Sellar R, McBride D, Millar RP, Dunn IC.
   The chicken type III GnRH receptor homologue is predominantly expressed in the pituitary, and exhibits similar ligand selectivity to the type I receptor.
   Journal of Endocrinology, 2009, 202: 179 - 190.
9. Reynolds RM, Logie JJ, Roseweir AK, McKnight AJ, Millar RP.
   A role of kisspeptins in pregnancy: facts and speculations
   Reproduction, 2009, 138: 1 - 7.
10. Bouligand J, Ghervan C, Tello JA, Brailly-Tabard S, Salenave S, Chanson P, Lombès M, Millar RP, Guiochon-Mantel A, Young J.
    Isolated Familial Hypogonadotropic Hypogonadism and a GNRH1 Mutation.
    New England Journal of Medicine, 2009, 360(26): 2742 - 2748
11. Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP.
    Discovery of Potent Kisspeptin Antagonists Delineate Physiological Mechanisms of Gonadotropin Regulation.
    Journal of Neuroscience, 2009, 29(12): 3920 - 3929
12. Roseweir AK, Millar RP.
    The role of kisspeptin in the control of gonadotrophin secretion.
    Human Reproduction Update, 2009, 15(2): 203 - 212
13. White CD, Coetsee M, Morgan K, Flanagan CA, Millar RP, Lu ZL.
    A crucial role for Galphaq/11, but not Galphai/o or Galphas, in gonadotropin-releasing hormone receptor-mediated cell growth inhibition.
    Mol Endocrinol. 2008 Nov;22(11):2520-30. Epub 2008 Sep 18.
14. Clarke IJ, Sari IP, Qi Y, Smith JT, Parkington HC, Ubuka T, Iqbal J, Li Q, Tilbrook A, Morgan K, Pawson AJ, Tsutsui K, Millar RP, Bentley GE.
    Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion.
    Endocrinology. 2008 Nov;149(11):5811-21. Epub 2008 Jul 10.
15. Coetsee M, Millar RP, Flanagan CA, Lu ZL
    Identification of Tyr(290(6.58)) of the human gonadotropin-releasing hormone (GnRH) receptor as a contact residue for both GnRH I and GnRH II: importance for high-affinity binding and receptor activation.
    Biochemistry. 2008 Sep 30;47(39):10305-13. Epub 2008 Sep 5.
16. Stewart AJ, Sellar R, Wilson DJ, Millar RP, Lu ZL
    Identification of a novel ligand binding residue Arg38(1.35) in the human gonadotropin-releasing hormone receptor.
    Mol Pharmacol. 2008 Jan;73(1):75-81. Epub 2007 Oct 17
17. Roseweir AK, Millar RP.
    The role of kisspeptin in the control of gonadotrophin secretion.
    Hum Reprod Update. 2009 Mar-Apr;15(2):203-12. Epub 2008 Dec 24

 

Denver Hendricks

1. Chellan P, Shunmoogam-Gounden N, Hendricks DT, Gut J, Rosenthal PJ, Lategan C, Smith PJ, Chibale K, Smith GS.
   Synthesis, Structure and in Vitro Biological Screening of Palladium(II) Complexes of Functionalised Salicylaldimine Thiosemicarbazones as Antimalarial and Anticancer Agents.
   European Journal of Inorganic Chemistry, 2010, 3520 - 3528.
2. Van Der Watt PJ, Maske CP, Hendricks DT, Parker MI, Denny L, Govender D, Birrer MJ, Leaner VD.
   The Karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.
   International Journal of Cancer, 2009, 124: 1829 - 1840
3. Stringer T, Chellan P, Therrien B, Shunmoogam-Gounden N, Hendricks DT, Smith GS.
   Synthesis and structural characterization of binuclear palladium(II) complexes of salicylaldimine dithiosemicarbazones
   Polyhedron, 2009, 28: 2839 - 2846
4. Van der Watt PJ, Maske CP, Hendricks DT, Parker MI, Denny L, Govender D, Birrer MJ, Leaner VD.
   The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.
   Int J Cancer. 2008 Nov 11. [Epub ahead of print]
5. van Wyk AW, Gray CA, Whibley CE, Osoniyi O, Hendricks DT, Caira MR, Davies-Coleman MT.
   Bioactive metabolites from the South African marine mollusk Trimusculus costatus.
   J Nat Prod. 2008 Mar;71(3):420-5. Epub 2008 Feb 21.

 

Virna Leaner

1. Leaner VD, Chick JF, Donninger H, Linniola I, Mendoza A, Khanna C, Birrer MJ.
   Inhibition of AP-1 Transcriptional Activity Blocks the Migration, Invasion, and Experimental Metastasis Murine Osteosarcoma.
   American Journal of Pathology, 2009, 174(01): 265 - 275
2. Calvisi DF, Donninger H, Vos MD, Birrer MJ, Gordon L, Leaner VD, Clark GJ.
   NORE1A Tumor Suppressor Candidate Modulates p21CIP1 via p53.
   Cancer Research, 2009, 69(11): 4629 - 4637.
3. Leaner VD, Chick JF, Donninger H, Linniola I, Mendoza A, Khanna C, Birrer MJ.
   Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma.
   Am J Pathol. 2009 Jan;174(1):265-75. Epub 2008 Dec 12.
4. Copley L, van der Watt P, Wirtz KW, Parker MI, Leaner VD.
   Photolon, a chlorin e6 derivative, triggers ROS production and light-dependent cell death via necrosis.
   Int J Biochem Cell Biol. 2008;40(2):227-35. Epub 2007 Aug 1

 

Iqbal Parker

1. Abrahaams A, Parker MI, Prince S.
   The T-box Transcription Factor Tbx2: Its Role in Development and Possible Implication in Cancer.
   IUBMB Life, 2010, 62(2): 92 - 102.
2. Kaschula CH, Hunter R, MI Parker
   Garlic-derived anticancer agents: Structure and biological activity of ajoene
   Biofactors, 2010, 36(1) 78 - 85.
3. Li D, Dandara C, Parker MI.
   The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer.
   BMC Genetics, 2010, 11(47): 1 - 9.
4. Wang B, Khachigian LM, Esau L, Birrer MJ, Zhao X, Parker MI, Hendricks DT.
   A Key Role for Early Growth Response-1 and Nuclear Factor-kB in Mediating and Maintaining GRO/CXCR2 Proliferative Signalling in Esophageal Cancer.
   Molecular Cancer Research, 2009, 7(5): 755 - 764
5. Torniainen S, Parker MI, Holmberg V, Lahtela E, Dandara C, Jarvela I.
   Screening of Variants for lactase persistence/non-persistence in populations from South Africa and Ghana.
   BioMed Central Genetics, 2009 July 5th doi:10.1186/1471-2156/10/31
   (Online journal - no page numbers, volumes etc.)
6. Teng H, Parker MI, Prince S.
   Functional characterization of cis-acting elements involved in basal transcription of the human Tbx2 gene: a new insight into the role of Sp1 in transcriptional regulation.
   Gene. 2008 Oct 15;423(1):8-13. Epub 2008 Jun 21.
7. Li DP, Dandara C, Walther G, Parker MI
   Genetic polymorphisms of alcohol metabolising enzymes: their role in susceptibility to oesophageal cancer.
   Clin Chem Lab Med. 2008;46(3):323-8.
8. Donninger H, Binder A, Bohm L, Parker MI.
   Differential effects of novel tumour-derived p53 mutations on the transformation of NIH-3T3 cells.
   Biol Chem. 2008 Jan;389(1):57-67.
9. Abrahams A, Mowla S, Parker MI, Goding CR, Prince S
   UV-mediated regulation of the anti-senescence factor Tbx2.
   J Biol Chem. 2008 Jan 25;283(4):2223-30. Epub 2007 Nov 19.

 

Trevor Sewell

1. Williamson DS, Dent KC, Weber BW, Varsani A, Frederick J, Thuku RN, Cameron RA, van Heerden JH, Cowan DA, Sewell BT.
   Structural and biochemical characterization of a nitrilase from the thermophilic bacterium, Geobacillus pallidus RAPc8.
   Applied Microbiology and Biotechnology, 2010, 88: 143 - 153.
2. Petersen LN, Marineo S, Mandalà S, Davids F, Sewell BT, Ingle RA.
   The Missing Link in Plant Histidine Biosynthesis: Arabidopsis myoinositol monophosphatase-like2 Encodes a Functional Histidinol-Phosphate Phosphatase1[W] [OA] .
   Plant Physiology, 2010, 152: 1186 - 1196.
3. van Rooyen JM, Abratt VR, Belrhali H, Sewell BT.
   Crystallization of recombinant Bacteroides fragilis glutamine synthetase (GInN) isolated using a novel and rapid purification protocol.
   Protein Expression and Purification, 2010, 74: 211 - 216.
4. Joubert MK, Kinsley N, Capovilla A, Sewell BT, Jaffer MA, Khati M.
   A Modeled Structure of an Aptamer-gp120 Complex Provides Insight into the Mechanism of HIV-1 Neutralization.
   Biochemistry, 2010, 49: 5880 - 5890.
5. Gildenhuys S, Dobreva M, Kinsley N, Sayes Y, Burke J, Pelly S, Gordon GP, Sayed M, Sewell BT, Dirr HW.
   Arginine 15 stabilizes an SNAr reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1.
   Biophysical Chemistry, 2010, 146: 118 - 125.
6. Opperman DJ, Sewell BT, Litthauer D, Isupov MN, Littlechild JA, van Heerden E.
   Crystal structure of a themostable Old Yellow Enzyme from Thermus scotoductus SA-01.
   Biochemical and Biophysical Research Communications, 2010, 393: 426 - 431.
7. Woodward JD, Sewell BT.
   Tomography of asymmetric bulk specimens imaged by scanning electron microscopy.
   Ultramicroscopy, 2010, 110: 170 - 175.
8. Achilonu I, Gildenhuys S, Fisher L, Burke J, Fanucchi S, Sewell BT, Fernandes M, Dirr HW.
   The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function.
   Acta Crystallographica Section F, 2010, F66: 776 - 780.

 

Lutz Thilo

1. de Chastellier C, Forquet F, Gordon A, Thilo L.
   Mycobacterium requires an all-around closely apposing phagosome membrane to maintain the maturation block and this apposition is re-established when it rescues itself from phagolysosomes.
   Cellular Microbiology, 2009, 11(08): 1190 - 1207

 

Cynthia Sikakhana

1. Sikakhana, CNT.
   Supporting student-doctors from under-resourced educational backgrounds: an academic development programme.
   Medical Education, 2010, 44: 917 - 925.