Helicobacter pylori - Current Research

 

 Eradication efficacy of treatment regimes

  1. Louw JA, Marks IN. Helicobacter pylori: Therapeutic targets. Yale J Biol Med 71(2):113-7, 1998
  2. Louw JA, van Rensburgh CJ, Moola S et al. Helicobacter pylori eradication and ulcer healing with daily lansoprazole, plus 1 or 2 weeks co-therapy with amoxicillin and clarithromycin. Aliment Pharmacol Ther 12(9):881-885, 1998.
  3. Louw JA, van Rensburgh CJ, Hanslo D et al. Two-week course of pantoprazole combined with 1 week of amoxycillin and clarithromycin is effective in Helicobacter pylori eradication and duodenal ulcer healing. Aliment Pharmacol Ther 12(6):545-50, 1998.
  4. Pounder RE, Wyeth JW, Duggan AE et al. Ranitidine bismuth citrate with clarithromycin for the eradication of Helicobacter pylori and for ulcer healing. Helicobacter 2(3):132-9, 1997.
  5. Van Rensburgh CJ, Louw JA, Girdwood AH et al. A trial of lansoprazole in refractory gastric ulcer. Aliment Pharmacol Ther 10(3):381-6, 1996.
  6. Louw JA, Lucke W, Jaskiewicz K, et al. Helicobacter pylori eradication in the African setting, with special reference to reinfection and duodenal ulcer recurrence. Gut 36(4):544-547, 1995.

 

Relationship between H. pylori and gastric pathophysiology

  1. Kidd M, Lastovica A, Atherton JC, Louw JA. Heterogeneity in the Helicobacter pylori vacA and cagA genes: Associated with gastroduodenal disease in South Africa? GUT 45(4):499-502, 1999
  2. Kidd M, Louw JA, Marks IN. Helicobacter pylori in Africa: Observations on an "enigma within an enigma". J Gastro Hepatol 14(9):851-8, 1999
  3. Letley DP, Lastovica A, Louw JA et al. Vacuolating cytotoxin gene in South Africa: Rarity of the vacAs1a genotype and natural occurence of an s2m1 allele. J Clin Microbiol 37(4):1203-5, 1999
  4. Louw JA, Young GO, Lucke W et al. Basal and pentagastrin stimulated acid secretion in duodenal ulcer subjects before and after Helicobacter pylori eradication: a 12-month follow-up study. Ital J Gastroenterol Hepatol 30(4):363-7, 1998.
  5. Louw JA, Modlin IM, Tang LH et al. Changes in the mucosal levels of transforming growth factor-alpha from the oxyntic region and ulcer site during duodenal ulcer healing with ranitidine or sucralfate. J Int Med Res 26(2):82-6, 1998.
  6. Letley DP, Lastovica A, Louw JA, et al. Analysis of vacA diversity among Helicobacter pylori isolates from South Africa reveals existence of a vacA s2/m1 allelle. Gastroenterol 113:A458, 1998.
  7. Trey G, Marks IN, Louw JA et al. Changes in acid secretion over the years. A 30-year longitudinal study. J Clin Gastroenterol 25(3):499-502, 1997.
  8. Kidd M, Miu K, Tang LH et al. Helicobacter pylori lipopolysaccharide stimulates histamine relase and DNA synthesis in rat enterochromaffin-like cells. Gastroenterol 113(4):1110-7, 1997.

 

Importance in non-ulcer dyspepsia

  1. Blum AL, Talley NJ, O'Morain C et al. Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. Omeprazole plus Clarithromycin and Amoxicillin effect one year after treatment (OCAY) study group. N Engl J Med 339(26):1875-1881, 1998.

 

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