ASSOC. PROF. EDWARD OJUKA

    BACK

    POSITION

    • Associate Professor, UCT/MRC Research Unit for Exercise Science and Sports Medicine (ESSM), Department of Human Biology, Faculty of Health Sciences, University of Cape Town

     

    QUALIFICATIONS

     

    • PhD (Exercise Physiology), Brigham Young University, Utah, USA (1994)

    Thesis title: Cocaine and exercise: Alterations in carbohydrate metabolism in adrenodemedullated rats

    • MEd (Curriculum and Instruction), Makerere University, Kampala, Uganda (1989)

    • BSc (Physics), Makerere University, Kampala, Uganda (1979)

     

     

    ESSM RESEARCH GROUP

    • Exercise in the management of chronic diseases

     

    RESEARCH INTERESTS

     

    • Role of CaMK in GLUT-4 regulation

    • NRF-1 and GLUT-4 regulation: Does NRF-1 regulate MEF-2 expression in vivo?

    • Role of calcium in the regulation of mitochondrial biogenesis

     

    OTHER

    • C-rated research scientist, National Research Foundation, South Africa

    • Faculty of Health Sciences Board Member, University of Cape Town

     

    CONTACT

     

    Tel:      +27 21 650 4576

    Email:  Edward.Ojuka@uct.ac.za

    BACK TO TOP

    PUBLICATIONS

     

    1. James A. H. Smith, Tertius Kohn, Ashley K Chetty and Edward O. Ojuka. CaMK activation during exercise is required for histone hyper-acetylation and MEF2A binding at the MEF2 site on the Glut4 gene. Am J Physiol Endocrinol metab 295: E698 - E704, 2008. Journal Impact factor 4.138, Number of citations 0 (recent publication).

    2. Mukwevho E, Kohn A.T, Lang D, Nyatya E, Smith J and Ojuka E.O. Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a caMK-dependent mechanism. Am J Physiol Endocrinol metabo 294: E582-E588, March 2008. Journal Impact factor 4.138 , Number of citations 0 (recent publication)

    3. Smith J. A, Collins M, Grobler L.A., Magee C. J. and Ojuka E. O. Exercise and CaMK activation both increase the binding of MEF2A to the Glut4 promoter in skeletal muscle in vivo. Am J Physiol Endocrinol Metab. 292:E413-E420, Feb 2007. Journal Impact factor 4.138, Number of citations 6

    4. Ojuka, E.O. Role of calcium and AMPK in the regulation of mitochondrial biogenesis and GLUT-4 levels in muscle. Proc. Nutr. Soc. 63(2): May 2004. Journal Impact factor 3.931, Number of citations 28

    5. Ojuka, E. O., Jones T. E., Dong-Ho Han, Chen M., and J. O.Holloszy. Raising Ca2+ in L6 myotubes mimics effects of exercise on mitochondrial biogenesis in muscle. FESEB J. 17, 675-681, April 2003. Journal Impact factor 6.791, Number of citations 56

    6. Baar K, Song Z, Semekovich C. F, Jones T. E., Han Dong-Ho, Nolte L, Ojuka E. O., Chen M., and J. O. Holloszy. Skeletal muscle overexpression of Nuclear Respiratory Factor 1 increases glucose transport capacity. FASEB J 17, 1666-1673, 2003. Journal Impact factor 6.792, Number of citations 21

    7. Jones, E. T., K. Baar, L. A. Nolte, E. O. Ojuka, and J. O. Holloszy.  Exercise induces an increase in muscle UCP3 as a component of the increase in mitochondrial biogenesis: Am J Physiol Endocrinol Metab. 284: E96-E101, 2003. Journal Impact factor 4.138 , Number of citations 18

    8. Ojuka, E. O., T. E. Jones, Dong-Ho Han, M. Chen, B. R. Wamhoff, M. Sturek, and J. O Holloszy.  Intermittent increases in cytosolic Ca2+ stimulate mitochondrial biogenesis in muscle cells: Am J Physiol Endocrinol Metab. 283: E1040-E1045, 2002. Journal Impact factor 4.138, Number of citations 28

    9. Ojuka, E. O., T. E. Jones, L. A. Nolte, M. Chen, B. R. Wamhoff, M. Sturek, and J. O. Holloszy.  Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca2+.  Am J Physiol Endocrinol Metab. 282: E1008-E1013, 2002. Journal Impact factor 4.138, Number of citations 66

    10. Ojuka, E. O., L. A. Nolte, and J. O. Holloszy.  Increased expression of GLUT4 and hexokinase in rat epitroclearis muscle exposed to AICAR in vitro. J Appl Physiol 88: 1072-1075, 2000. Journal Impact factor 3.632, Number of citations 77.

    11. Conlee, R.K., P.K. Kelly, E.O. Ojuka, and R.L. Hammer.  Cocaine and exercise: a-1 receptor blockade does not alter muscle glycogenolysis and blood lactacidosis. J Appl Physiol 88:77-81, 2000. Journal Impact factor 3.632, Number of citations1

    12. Ojuka E.O., Bell J. D., Fellingham G. W., and Conlee R. K. Cocaine and Exercise: Alteration in carbohydrate metabolism in adrenodemedullated rats. J. Appl. Physiol. 80: 124-132, 1996. Journal Impact factor 3.632, Number of citations 2

    13. Winder W.W., Fisher S.R., Gygi S. P., Mitchell J.A. Ojuka E.O. and D.A. Weidman. Divergence of muscle and liver fructose 2, 6,-diphosphate in fasted exercising rats. Am. J. Physiol. 260: E756-E761, 1991. Journal Impact factor 4.138 , Number of citations 13

    BACK TO TOP