|
| CHEMICAL PATHOLOGY JOURNAL CLUB - FORTHCOMING PRESENTATIONS |
The Journal Club on Monday, 20 May 2013 at 11h45
will be presented by Dr Hendre Swanepoel
Topic:
Vitamin B12 Deficiency
S P Stabler
NEJM 368 (2):149-160 (10 Jan 2013)
(a clinical practice review article)
Venue:
Conference Room 6.22 on level 6 in Division of Chemical Pathology, Falmouth Bdg All welcome |
Journal Clubs for 2013 »
| Date (2013) |
Speaker |
Topic |
| 04 Feb |
David M |
Luevano-Contreras C, et al. Role of dietary advanced glycation end products in diabetes mellitus.
J Evidence-Based Complementary & Alternative Medicine. 2013;18:50-66. |
| 11 Feb |
Nalene |
|
| 18 Feb |
Chilu |
|
| 25 Feb |
Celeste |
|
 |
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|
| 04 Mar |
Mbali |
Utility and limitations of biochemical markers of vitamin B12 deficiency
Herrmann, W. and Obeid, R. European Journal of Clinical Investigation 2013; 43 (3): 231-237 |
| 11 Mar |
David H |
Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes
Cell Metabolism:17(3):448-455, 5 March 2013 |
| 18 Mar |
CANCELLED |
|
| 25 Mar |
Hendre |
Hydrogen sulfide as an oxygen sensor-a mini review
Kenneth R. Olson
Clin Chem Lab Med 2013; 51(3): 623-632 (March issue) |
|
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| 01 Apr |
HOLIDAY |
|
| 08 Apr |
Fierdoz |
|
| 15 Apr |
Philip |
|
| 22 Apr |
Chilu |
Increased brain uptake and oxidation of acetate in heavy drinkers
Jiang et al.
J Clin Invest 2013; 123(4):1605-1614 |
| 29 Apr |
Celeste |
|
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|
|
| 06 May |
David M |
|
| 13 May |
Mbali |
Multiplex Immunoassays of Peptide Hormones Extracted from Formalin-Fixed, Paraffin-Embedded Tissue Accurately Subclassify Pituitary Adenomas
Strathmann F.G., et al.
Clin Chem 2012;58(2):366-374 |
| 20 May |
Hendre |
|
| 27 May |
Surita |
|
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|
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| 03 Jun |
George |
|
| 10 Jun |
Chilu |
|
| 17 Jun |
HOLIDAY |
|
| 24 Jun |
Fierdoz |
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| 01 Jul |
Joy |
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| 08 Jul |
George |
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| 15 Jul |
VACATION |
|
| 22 Jul |
VACATION |
|
| 29 Jul |
LABMED |
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| 05 Aug |
Mbali |
|
| 12 Aug |
Dee |
|
| 19 Aug |
Philip |
|
| 26 Aug |
Hendre |
|
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| 02 Sep |
David M |
|
| 09 Sep |
Chilu |
|
| 16 Sep |
Mbali |
|
| 23 Sep |
Surita |
|
| 30 Sep |
Fierdoz |
|
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| 07 Oct |
Hendre |
|
| 14 Oct |
George |
|
| 21 Oct |
Philip |
|
| 28 Oct |
Chilu |
|
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| 04 Nov |
David M |
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| 11 Nov |
Mbali |
|
| 18 Nov |
Hendre |
|
| 25 Nov |
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|
ARCHIVES
Journal Clubs for 2012
| Date (2012) |
Speaker |
Topic |
| 06 Feb |
David M |
Oxidized high-density lipoprotein as a risk factor for cardiovascular events in prevalent hemodialysis patients
Hirokazu Hondaa et al
Atherosclerosis 220 (2012) 493– 501 |
| 13 Feb |
John |
The Athlete Biological Passport
Sottas P et al
Clin Chem 57:7:969-76 (2011) |
| 20 Feb |
Nalene |
Review Article
Update on investigating hypoglycaemia in childhood
Timothy F Lang
Ann Clin Biochem 2011; 48: 200-211. DOI: 10.1258/acb.2011.011012
|
| 27 Feb |
Celeste |
Diagnostic Potential of Saliva: Current State and Future Applications
Clinical Chemistry May 2011 vol.57 no.5 675-687 |
|
|
|
| 05 Mar |
ETHICS: Nada |
Euthanasia |
| 12 Mar |
Fierdoz |
|
| 19 Mar |
ETHICS: Lauraine |
Circumcision |
| 26 Mar |
CANCELLED |
|
|
|
|
| 02 Apr |
Neil Harris |
Metal Toxicity |
| 09 Apr |
HOLIDAY |
|
| 16 Apr |
George |
|
| 23 Apr |
Chilu |
IL-15 triggers an antiapoptotic pathway in human intraepithelial
lymphocytes that is a potential new target in coeliac disease-associated
inflammation and lymphomagenesis
Malamut G, Machhour R et al
J Clin Invest 2010; Vol 120(6):2131-2143 |
| 30 Apr |
CANCELLED |
|
|
|
|
| 07 May |
David H |
A PGC1-a-dependent myokine that drives brown-fat-like development of
white fat and thermogenesis
Nature 481: 463 (26 January 2012) |
| 14 May |
ETHICS: Frieda |
|
| 21 May |
Pete |
1. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes Nature 20 July 2010
2. SIRT3 regulates mitochondrial fatty acid oxidation by reversible enzyme deacetylation Nature 4 March 2010
3. (if there's time) Central control of fever and female body temperature by RANKL/RANK Nature 26 November 2009 |
| 28 May |
CANCELLED |
|
|
|
|
| 04 Jun |
Philip |
Rehfeld, J. F. (2012) Pitfalls in Diagnostic Gastrin Measurements.
Clin
Chem 58: 831-836
Rehfeld, J. F. (2011) The Zollinger-Ellison Syndrome and Mismeasurement
of Gastrin.
Gastroenterology 140: 144-1453 |
| 11 Jun |
Nalene |
|
| 18 Jun |
David M |
Infection regulates pro-resolving mediators that lower antibiotic
requirements
Chiang N, et al.
Nature 2012;484:524-528 |
| 25 Jun |
CANCELLED |
|
|
|
|
| 02 Jul |
Philip |
Thanatochemistry
Camille Boulagnon, Roselyne Garnote, Paul Fornes and Philippe Gillery
Clin Chem Lab Med 2011;49(8):1265–1270 |
| 09 Jul |
Dr Jialal |
Diabetes is a pro-inflammatory state: Implications for vascular complications. |
| 16 Jul |
VACATION |
|
| 23 Jul |
Chilu |
Thyroid hormone stimulates hepatic lipid catabolism via activation of
autophagy
Sinha, You et al.
J. Clin. Investigation 2012; vol.122 (7) 2428-2438 |
| 30 Jul |
Celeste |
|
|
|
|
| 06 Aug |
Fierdoz |
|
| 13 Aug |
George |
|
| 20 Aug |
David H |
Low Circulating Adropin Concentrations with Obesity and Aging Correlate with Risk Factors for Metabolic Disease and Increase after Gastric Bypass Surgery in Humans
J Clin Endocrinol Metab, October 2012, 97(10)
Detecting growth hormone abuse in athletes
Anal Bioanal Chem (2011) 401:449–462 |
| 27 Aug |
Celeste |
|
|
|
|
| 03 Sep |
Mbali |
Inappropriate Requesting of Glycated Haemoglobin (HbA1c) is widespread.
Drickell OJ, Holland D, Hanna FW, et al.
Clin Chem 2012;58(5)906-915 |
| 10 Sep |
Chilu |
|
| 17 Sep |
David M |
|
| 24 Sep |
HOLIDAY |
|
|
|
|
| 01 Oct |
PATH CONGRESS |
|
| 08 Oct |
Mbali |
Diagnostic utility of osteocalcin, undercarboxylated osteocalcin and
alkaline phosphatase for osteoporosis in premenopausal and
postmenopausal women
Annals of Laboratory Medicine 2012;32:23-30
Atalay S, et al |
| 15 Oct |
David M |
Structural basis of Wolman Disease and cholesteryl ester storage disease.
Saito S, et al.
Mol Gen Metab 2012;105:244-248. |
| 22 Oct |
Fierdoz |
|
| 29 Oct |
Ryan |
A polemic on stochastic processes in clinical chemistry |
|
|
|
| 05 Nov |
Philip |
Neutrophils mediate insulin resistance in mice fed a high-fat diet
through secreted elastase
Talukdar et al.
Nature Medicine (2012) 18:1407-1414 |
| 12 Nov |
SYMPOSIUM |
|
| 19 Nov |
George |
|
| 26 Nov |
David H |
Impact of caloric restriction on health and survival in rhesus monkeys
from the NIA study
Nature 2012 Sep 13;489(7415):318-21
Fasting time and lipid levels in a community-based population
Arch Intern Med. Published online November 12, 2012 |
|
|
|
| 3 Dec |
Surita |
|
Journal Clubs for 2011
| Date (2011) |
Speaker |
Topic |
| 31 Jan |
Sumbukeni |
Persistently Increased Acetaminophen Concentrations in a Patient with Acute Liver Failure.
Fong et al.
Clinical Chemistry 57:1 (2011). |
|
|
|
| 07 Feb |
John |
Enhanced Weight Loss with Pramlintide/Metreleptin: An Integrated Neurohormonal Approach to Obesity Pharmacotherapy.
Ravussin et al.
Obesity 17: 1736–1743 (2009) |
| 14 Feb |
Chilu |
van Deventer et al.
Inverse Log Linear Relationship between Thyroid Stimulating Hormone and
Free Thyroxine Measured by Direct Analog Immunoassay and Tandem Mass
Spectrometry
Clin Chem 57:1,122-127(2011) |
| 21 Feb |
David |
In Vivo Activity of the Thyroid Hormone Receptor beta- and alpha-Selective Agonists GC-24 and CO23 on Rat Liver, Heart, and Brain
Endocrinology, March 2011, 152(3)
A New Small-Molecule Antagonist Inhibits Graves’ Disease Antibody Activation of the TSH Receptor
J Clin Endocrinol Metab 96:548–554, 2011
Thyronamines—Past, Present, and Future
Endocrine Reviews 32: 64–80, 2011 |
| 28 Feb |
George |
|
|
|
|
| 07 Mar |
Ryan |
|
| 14 Mar |
CANCELLED |
|
| 21 Mar |
HOLIDAY |
|
| 28 Mar |
David |
FGF19 as a Postprandial Insulin-Independent Activator of Hepatic
Protein and Glycogen Synthesis
Science 331(4):1621 (2011 Mar) |
|
|
|
| 04 Apr |
John |
|
| 11 Apr |
Nolwazi |
Urinary Catalytic Iron in Obesity
Tina K. Thethi et al.
Clinical Chemistry 57:272-278 (2011)
|
| 18 Apr |
Fierdoz |
Hepcidin and Thalassaemia |
| 25 Apr |
HOLIDAY |
|
|
|
|
| 02 May |
HOLIDAY |
|
| 09 May |
Ryan |
|
| 16 May |
Pete |
Adiponectin and adipoR1 regulate PGC-1a and mitochondria by Ca2+ and
AMPK/SIRT1
Iwabu et al
Nature 29 April 2010 pp 1313-1319 |
| 23 May |
Philip |
|
| 30 May |
Ryan |
Perilipin deficiency and autosomal dominant partial lipodystrophy
Gandotra et al.
NEJM 2011: 364(8): 740-748 |
|
|
|
| 06 Jun |
George |
|
| 13 Jun |
Pete |
|
| 20 Jun |
Fierdoz/Philip |
Report-back on the recent IFCC meeting they attended in Berlin. |
| 27 Jun |
Nolwazi |
Serum concentrations of retinol-binding protein 4 in women with and
without gestational diabetes
Diabetologia 51:1115-1122 (2008)
Krzyzanowska, K et al. |
|
|
|
| 04 Jul |
Carel |
Carel reported back on the congress he recently
attended and presented at in Cardiff, Wales. The topic was "Porphyria". |
| 11 Jul |
Ify |
Evaluation of salivary melatonin measurements for Dim Light Melatonin
Onset calculations in patients with possible sleep-wake rhythm
disorders
Clin Chim Acta 412: 1616 (2011) |
| 18 Jul |
Fierdoz |
|
| 25 Jul |
John |
|
|
|
|
| 01 Aug |
Carel |
Incremental value of HS TropT for risk prediction in patients with
suspected AMI
Clin Chem 57:9 (2011)
A national survey of interpretive reporting in the UK
ACB 48:317-320 (2011) |
| 08 Aug |
CANCELLED |
|
| 15 Aug |
Nalene |
Preanalytical quality improvement: from dream to reality
Lippi et al
Clinical Chemistry in Laboratory Medicine 49(7):1113-1126 (2011) |
| 22 Aug |
Philip |
Mutations in CYP24A1 and Idiopathic Infantile Hypercalcemia
Schlingmann, K. et al.
NEJM 365(5)(2011) |
| 29 Aug |
CANCELLED |
|
|
|
|
| 05 Sep |
PATH CONGRESS |
|
| 12 Sep |
Chilu |
Cosmo et al., Mice deficient in mct-8 reveal a mechanism regulating
thyroid hormone secretion.
J.Clin.Invest. 2010, 120 (10). |
| 19 Sep |
Ify |
Serum hepcidin-25 in comparison to biochemical markers and
haematological indices for the differentiation of iron-restricted
erythropoiesis
Clin Chem Lab Med 2011;49(2):207-213 |
| 26 Sep |
Chilu |
Nicotinic acid inhibits progression of atherosclerosis in mice through
its receptor GPR109A expressed by immune cells
Lukasova M. et al.
J. Clin. Invest. 2011;121(3):1163-1173 |
|
|
|
| 03 Oct |
George |
|
| 10 Oct |
Nalene |
Streichert et al.
Determination of Hemolysis Thresholds by the Use of Data Loggers in
Pneumatic Tube Systems
Clinical Chemistry 57:10,1390-1397(2011) |
| 17 Oct |
Carel |
Novel Loss-of-Function PCSK9 Variant Is Associated with Low Plasma LDL Cholesterol in a French-Canadian Family and with Impaired Processing and Secretion in Cell Culture.
Mayne J, Dewpura T, Raymond A, Bernier L, Cousins M, Ooi TC, Davignon J, Seidah NG, Mbikay M, Chrétien M.
Clin Chem. 2011 Oct;57(10):1415-23 |
| 24 Oct |
David |
Relationship between Urinary Bisphenol A Levels and Diabetes Mellitus
J Clin Endocrinol Metab 96(12) (2011)
Urinary Bisphenol A and Obesity
Environ Res 111(6):825-30 (2011 |
| 31 Oct |
Chilu |
ProBNP 1-108 is Resistant to Degradation and Activates Guanylyl
Cyclase-A with Reduced Potency
Dickey D and Potter L
Clin Chem 57(9): 1272-1278 (2011) |
|
|
|
| 07 Nov |
Philip |
Rescue of obesity-induced infertility in female mice due to a
pituitary-specific knockout of the insulin receptor.
Brothers et al
Cell metabolism 12: 295-305 (2010)
|
| 14 Nov |
Ryan |
|
| 21 Nov |
Pete |
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR-gamma by Cdk5
Choi et al
Nature 22 July 2010 |
| 28 Nov |
John |
Rapid and Specific Quantification of Ethylene Glycol Levels -
Adaptation of a Commercial Enzymatic Assay to Automated Chemistry
Analyzers
Juenke et al.
Am J Clin Pathol 2011;136:318-324 |
Journal Clubs for 2010
| Date (2010) |
Speaker |
Topic |
| 01 Feb |
Pete |
Various topics including:
'brown adipose tissue' (New England Journal of Medicine, April 2009)
'Regulation of adaptive behaviour during fasting by hypothalamic Foxa2' (Nature, 3 Dec 2009)
|
| 08 Feb |
Fierdoz |
Barnes AM et al. Lack of Cyclophilin B in osteogenesis imperfecta with normal collagen folding. NEJM 2010 (online ahead of publication) |
| 15 Feb |
Ryan |
TBA |
| 22 Feb |
George |
Rosengren AH, Jokubka R, Tojjar D, et al. Overexpression of
the alpha2A‑adrenergic receptors contributes to type2 diabetes.
Science, 8 Jan, 2010, (327) |
| 01 Mar |
John |
Rebecca W.Y. Chan, John Wong, Henry L.Y. Chan, Tony S.K. Mok, Wyatt Y.W. Lo, Vincent Lee, Ka F. To, Paul B.S. Lai, Timothy H. Rainer, Y.M. Dennis Lo, and Rossa W.K. Chiu.
Aberrant concentrations of liver‑derived plasma albumin mRNA in liver pathologies.
Clin Chem 56:1:82‑89 (2010) |
| 08 Mar |
David |
Leptin therapy in insulin‑deficient type I diabetes
From PNAS published ahead of print |
| 15 Mar |
Sumbukeni |
Assessment of Vitamin B12 Absorption Based on the Accumulation of Orally Administered Cyanocobalamin on Transcobalamin.
Hardlei et al.
Clinical Chemistry 56(3):432‑436 (2010) |
| 22 Mar |
HOLIDAY |
|
| 29 Mar |
Philip |
|
| 05 Apr |
HOLIDAY |
|
| 12 Apr |
Chilu |
Ischaemia‑modified albumin elevation after percutaneous coronary intervention reflects albumin concentration rather than ischaemia.
Annals of Clinical Biochemistry 46 (4): 327‑331 (2009)
Demir, H et al |
| 19 Apr |
Philip |
Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice
J Clin Invest 120 (4), April 2010 |
| 26 Apr |
HOLIDAY(27th) |
|
| 03 May |
Ryan |
Renal tubular acidosis with two unusual case reports
Singapore Med Case Report J 2010; 51(2) : e24
Indian Pediatr 2009;46: 532‑534 |
| 10 May |
Chilu |
High‑sensitivity cardiac troponin T for early prediction of evolving non‑ST segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission.
Giannitsis et al
Clin Chem 56(4): 642‑650 |
| 17 May |
Sumbukeni |
Zinc Supplementation Improves the Outcome of Chronic Hepatitis C and Liver Cirrhosis
M. Moriyama et al
J. Clin. Biochem. Nutr., 45, 292-303, November 2009 |
| 24 May |
David |
Presentation of his MMed thesis:
"Serum proteome changes after HIV infection" |
| 31 May |
John |
Report back on highlights of the recent Association of Clinical Biochemists (ACB) Focus 2010 Congress in Glasgow (10‑13 May 2010) |
| 07 Jun |
Chilu |
Urinary proteases degrade albumin: implications for measurement of albuminuria in stored samples
Kania et al
Annals of Clinical Biochemistry 47:151‑157 (2010) |
| 14 Jun |
David |
Ghrelin O-acyltransferase is essential for growth hormone-mediated
survival of calorie-restricted mice |
| 21 Jun |
Philip |
Case studies in calcium and phosphate metabolism |
| 28 Jun |
Ryan |
Folate regulation of axonal regeneration
in the rodent central nervous system
through DNA methylation
Bermans J et al
J Clin Invest 2010;120(5):1603–1616 |
| 05 Jul |
John |
Seven Direct Methods for Measuring HDL and LDL Cholesterol Compared
with Ultracentrifugation Reference Measurement Procedures
Miller, WG et al
Clinical Chemistry 56:6:977–986 (2010) |
| 12 Jul |
CANCELLED |
|
| 19 Jul |
Fierdoz |
MMed research project:
Investigation of High Molecular Weight Adiponectin in HIV‑Infected Patients on Antiretroviral Therapy |
| 26 Jul |
George |
MMed research project:
Mitochondrial DNA ratios in HIV‑positive children |
| 02 Aug |
Sumbukeni |
Efficacy and safety of exenatide once weekly as an adjunct to metformin for the treatment of type‑2 diabetes" (DURATION 2) : A randomised trial
Lancet online version of 26/06/2010 |
| 09 Aug |
HOLIDAY |
|
| 16 Aug |
Chilu |
Hedgehog signaling has a protective effect in glucocorticoid‑induced mouse neonatal brain injury through an 11βHSD2‑dependent mechanism
Heine and Rowitch
J Clin Invest 119(2):267‑277 (2009) |
| 23 Aug |
Pete |
1. Amino acid imbalance explains extension of lifespan by dietary restriction in Drosophila Nature 31 December 2009
2. A cognitively normal PDH‑deficient 18 year old man carrying the R263G mutation in the PDHA1 gene J. Inherit. Metab. Dis. 31 July 2009 |
| 30 Aug |
Philip |
Persistent increase of cardiac troponin I in plasma without evidence of cardiac injury
Clin. Chem. 56: 702‑707 (2010) |
| 06 Sep |
PATH CONGRESS |
|
| 13 Sep |
Ryan |
|
| 20 Sep |
John |
Vitreous Humor: Biochemical Constituents in Estimation of Postmortem
Interval
Jashnani KD, Kale SA & Rupani AB
J Forensic Sci 2010 July 28 [epub ahead of print] |
| 27 Sep |
George |
Vascular endothelial growth factor B controls endothelial fatty acid
uptake
Hagberg et al.
Nature Vol 464, 8 April 2010
The complete mitochondrial DNA genome of an unknown hominid from
southern Siberia
Krause et al.
Nature Vol 464, 8 April 2010 |
| 04 Oct |
David |
Report-back on the AACC 2010 conference in
Anaheim, CA |
| 11 Oct |
Sumbukeni |
Rethinking the Stalk Effect: A New Hypothesis Explaining Suprasellar
Tumour Induced Hyperprolactinemia
Donal C. Skinner
Med Hypotheses March 2009 |
| 18 Oct |
Chilu |
Resistance to thyroid hormone is associated with raised energy
expenditure, muscle mitochondrial uncoupling, and hyperphagia
Mitchell,Savage et al
Journal of Clinical Investigation 120(4), April 2010 |
| 25 Oct |
Fierdoz |
|
| 01 Nov |
Philip |
Cathepsin B inhibition interferes with metastatic potential of human
melanoma:
an in vitro and in vivo study
P Matarrese et al
Molecular Cancer 9:207-221 (2010) |
| 08 Nov |
CANCELLED |
|
| 15 Nov |
Ian Machingura |
The Genetic Basis of Nephropathy in Diabetic Patients |
| 22 Nov |
Ryan |
Leigh Syndrome
Complex I deficiency due to loss of Ndufs4 in the brain
results in progressive encephalopathy resembling Leigh syndrome.
Quintina et al. PNAS 2010 107(24): 10996-11001
Leigh and Leigh-like syndromes in children and adults.
Finsterer. Pediatric neurology 2008 39(4): 223-235
Leigh syndrome: clinical features and biochemical and DNA
abnormalities.
Rahman et al. Annals of Neurology 1996 39(3): 343-351
Subacute necrotizing encephalomyelopathy in an infant.
Leigh. Journal
of neurology, neurosurgery and psychiatry 1951 14: 216-221 |
| 6 Dec |
Pete |
1. Biochemical abnormalities in a patient with thymidine phosphorylase
deficiency with fatal outcome.
Bakker et al,
J Inherit. Metab. Dis. 2010
2. Molecular mechanisms of mtDNA depletion diseases caused by
deficiencies in enzymes in purine and pyrimidine metabolism. Eriksson & Wang,
Nucleosides, Nucleotides & Nucleic acids. 27:800 2008
3. Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase
(p53R2), causes severe mtDNA depletion. Bourdon et al
Nature Genetics 39:776 2007
4. Mutant mitochondrial thymidine kinase in mtDNA depletion myopathy.
Saada et al
Nature Genetics 29:342 2001
5. The deoxyguanosine kinase gene is mutated in individuals with
depleted hepatocerebral mtDNA. Mandel et al
Nature Genetics 29:337 2001
6. PGC-1alpha, a potential therapeutic target for early intervention in
Parkinson's Disease. Zeng et al.
Sci. Transl. Med. 2010 |
Journal Clubs for 2009
| Date (2009) |
Speaker |
Topic |
| 02 Feb |
Dr David Haarburger |
"Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse" |
| 09 Feb |
Dr Ryan Benjamin |
"The value of measurement of cystatin C in renal disease" |
| 16 Feb |
Prof TS Pillay |
"Please, SIR(T), may I have some more!.....Calorie restriction, aging, antioxidants and transcriptional regulation" |
| 23 Feb |
Dr John Stanfliet |
Standardization of High-Sensitivity Immunoassays for Measurement of C-Reactive Protein: Two Approaches for Assessing
Commutability of a Reference Material
Clin Chem(2009)55:2:342-350
Kimberly MM et al. |
| 02 Mar |
Dr Philip Fortgens |
Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney
J. Clin. Invest. 118(7):2525-2534 (2008) |
| 09 Mar |
Dr Peter Berman |
1. A receptor that mediates the post-mating switch in Drosophila reproductive behaviour.
Yapici et al Nature 3 Jan 2008
2. A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility.
Biver et al Nature 20 Nov 2008
3. The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes.
Graves et al Nature 5 June 2008
4. Structural basis for androgen specificity and oestrogen synthesis in human aromatase.
Ghosh et al Nature 8 Jan 2009 |
| 16 Mar |
Dr Vuyo Keti |
Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction Via AMPK-eNOS–Mediated Signaling
Diabetes 57:696-705, 2008 |
| 23 Mar |
Dr David Haarburger |
Genetically elevated C-reactive protein and ischemic vascular disease
N Engl J Med. 2008 Oct 30;359(18):1897-908.
Clinical practice. Carbon monoxide poisoning
N Engl J Med. 2009 Mar 19;360(12):1217-25
A family with complete resistance to thyrotropin-releasing hormone.
N Engl J Med. 2009 Feb 12;360(7):731-4
An unusual outbreak of hypoglycemia.
N Engl J Med. 2009 Feb 12;360(7):734-6
|
| 30 Mar |
Dr Jim Bonham |
EQA for IEM testing |
| 06 Apr |
Dr Chilu Chingwanda |
Mortality Results from a Randomized Prostate-Cancer Screening Trial
Andriole et al
N Engl J Med 2009;360(13):1310-1319 |
| 20 Apr |
Dr Fierdoz Omar |
|
| 04 May |
Dr George van der Watt |
Mechanism of age dependent susceptibility and novel treatment strategy in glutaric acidemia type 1
Zinnati et al
J Clin Invest 117(11):3258-70 |
| 11 May |
Dr John Stanfliet |
Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis.
Galluzzo et al.
J Clin Invest (2009):119;4:865-875 |
| 18 May |
Dr Philip Fortgens |
B-Type Natriuretic Peptide Testing, Clinical Outcomes, and Health Services Use in Emergency Department Patients With Dyspnea:
A Randomized Trial
Ann Intern Med. 2009;150:365-371 |
| 25 May |
Dr Vuyo Keti |
Genetic polymorphisms of the natriuretic peptide system in the pathogenesis of cardiovascular disease
Clin Chem 55:878-887, 2009
|
| 01 Jun |
Prof TS Pillay |
Protein phosphorylation and biochemical disease: selected examples.
"Nudge-Nudge; Wnk Wnk :)""A Hard Akt to follow "
Electrolyte regulation and hypertension
Biochem. J. (2004) 378, 257–268 ,257
WNK1, the kinase mutated in an inherited high-blood-pressure syndrome,
is a novel PKB (protein kinase B)/Akt substrate
J Clin Invest. 2007 April 2; 117(4): 1078–1087.
Intersectin links WNK kinases to endocytosis of ROMK1
Science 2004 May 28 304(5675) 1325-1328
A Family with Severe Insulin Resistance and Diabetes Mellitus due
to a Missense Mutation in AKT2 |
| 08 Jun |
Prof Howard Henderson |
mDNA sequencing, metabolomics in prostate cancer, autophagy in fat metabolism and endothelial lipase. |
| 22 Jun |
Dr Ryan Benjamin |
Thyroid hormones act indirectly to increase sex-hormone-binding globulin production by liver via hepatocyte nuclear factor 4 alpha.
Selva and Hammond
Journal of Molecular Endocrinology (July 2009, pre-print) |
| 29 Jun |
Dr John Stanfliet |
Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials.
K K Ray et al.
Lancet 2009;373:1765-72 |
| 06 Jul |
Dr David Haarburger |
Unbound (Free) Bilirubin: Improving the Paradigm for Evaluating Neonatal Jaundice
Clinical Chemistry 55:7 1288-1299 (2009) |
| 13 Jul |
Dr Chilu Chingwanda |
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.
Stanhope, Schwarz et al.
J Clin Invest 119(5): 1322-1334 (2009) |
| 20 Jul |
Dr Pete Berman |
1. Ethanol acutely stimulates islet blood flow, amplifies insulin secretion and induces hypoglycaemia via nitric oxide and vagally mediated mechanisms.
Huang et al. Endocrinology 2008
2. Mammalian sirtuins- emerging roles in physiology, aging and calorie restriction.
Haigis et al. Genes and development 2006 |
| 27 Jul |
Dr Vuyo Keti |
Type 2 Iodothyronine Deiodinase in Skeletal Muscle: Effects of Hypothyroidism and Fasting.
Karen et al.
J Clin Endocrinol Metab 2009 94: 2144-2150 |
| 03 Aug |
Dr Philip Fortgens |
Can licorice lick colon cancer?
J Clin Invest (2009) 119(4): 760-763 and 876-885 |
| 17 Aug |
Dr Ryan Benjamin |
|
| 24 Aug |
Dr John Stanfliet |
Antibodies against synthetic deamidated gliadin peptides for celiac disease diagnosis and follow-up in children.
Daniela Basso et al.
Clin Chem 55:150-7 (January 2009) |
| 31 Aug |
Dr Fierdoz Omar |
|
| 14 Sep |
Dr George van der Watt |
Tumours with PI3K activation are resistant to dietary restriction.
The authors show that mouse or human tumours in which the PI3K/Akt pathway is constitutively activated are resistant to dietary restriction whereas other tumours are sensitive. The authors also implicate the Akt target gene FOXO1 in the response to dietary restriction.
Nada Y. Kalaany & David M. Sabatini
Nature 458, 725-731 (9 April 2009) |
| 21 Sep |
Dr Philip Fortgens |
Dissociation of Pentameric to Monomeric C-Reactive Protein on Activated Platelets Localizes Inflammation to Atherosclerotic Plaques.
Steffen U. Eisenhardt et al.
Circulation Res. 105:128-137 (2009) |
| 28 Sep |
Dr Chilu Chingwanda |
Circulating calcitriol concentrations and total mortality.
Zitterman et al.
Clinical Chemistry 55;1163-1170,2009 |
| 05 Oct |
Prof TS Pillay |
1) The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts
J Clin Invest September 2009
2) Mitochondrial gene replacement in primate offspring and embryonic stem cells
Nature September 2009 |
| 12 Oct |
Dr Ryan Benjamin |
Serum free light chain assay reduces the need for serum and urine immunofixation electrophoresis in the evaluation of monoclonal gammopathy
Fulton and Fernando
ACB 2009 46:407-412
Serum free light chain analysis may miss monoclonal light chain disease that urine immunofixation may detect
Shaheen and Levinson
Clinica Chimica Acta 2009 406:162-166 |
| 26 Oct |
Dr Vuyo Keti |
Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I
J. Clin. Invest.119(9): 2737-2744 (September 1,2009) |
| 02 Nov |
Prof Howard Henderson |
AIDS, autophagy, endothelial lipase and "call back the past" |
| 09 Nov |
Dr Fierdoz Omar |
A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus.
The Journal of Clinical Investigation Volume 119 Number 10 October 2009 |
| 16 Nov |
Dr Pete Berman |
|
| 23 Nov |
Dr John Stanfliet |
Differences in Recognition of the 1st WHO International Reference Reagents for hCG-Related Isoforms by Diagnostic Immunoassays for Human Chorionic Gonadotropin
Sturgeon CM, Berger P, Bidart J, Birken S, Burns C, Norman R and Stenman U
Clinical Chemistry (2009) 55:8:1484-1491 |
| 30 Nov |
Dr David Haarburger |
Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in
X‑Linked Adrenoleukodystrophy
Science 326, 818 (6 November 2009)
|
Journal Clubs for 2008
| Date (2008) |
Speaker |
Topic |
| 04 Feb |
Dr Carel Haumann |
"Diagnosis of alpha-1-antitrypsin deficiency: an algorithm of quantification, genotyping and phenotyping"
Clin Chem 52:12: 2236-2242 (2006) |
| 11 Feb |
Dr Vuyokazi November |
Capellini MD, Fiorelli G
"Glucose-6-phosphate dehydrogenase deficiency"
Lancet 371:64-74 (2008) |
| 18 Feb |
Dr Pete Berman |
1. Co-operation and conflict in quorum-sensing bacterial populations.
2. Phagocyte-derived catecholamines enhance acute inflammatory injury.
3. p53 regulates maternal reproduction through LIF.
All articles are from recent editions of Nature. |
| 25 Feb |
Dr Ryan Benjamin |
"Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage." Muniyappa, Lee, Chen, Quon
Am J Physiol Endo Metab 294:E15-E26 (2008) |
| 03 Mar |
Dr Carel Haumann |
"Reactivity of Urinary Albumin (Microalbumin) Assays with Fragmented or Modified Albumin."
Clinical Chemistry 2008 54:1 61-68 |
| 10 Mar |
Dr Fierdoz Omar |
"Metabolomics Identifies Perturbations in Human Disorders of Propionate Metabolism"
Wikoff WR et al.
Clinical Chemistry 2007:53(12); 2169 |
| 31 Mar |
Dr John Stanfliet |
"Iron stores, blood donation and insulin sensitivity and secretion"
Journal of Clinical Chemistry 51: 1201-1205 (2005) |
| 07 Apr |
Prof Howard Henderson |
Neuronal fireworks
TLR-polymorphisms
SNP associations |
| 14 Apr |
Dr David Haarburger |
Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia.
PNAS 105: 4242-4246 (March 2008) |
| 21 Apr |
Dr Ryan Benjamin |
3-D cellular microarray for high-throughput toxicology assays.
PNAS 105: 59--63 (Jan 2008) |
| 05 May |
Dr Fierdoz Omar |
Adiponectin regulates albuminuria and podocyte function in mice.
Sharma et al,
J Clin Invest doi:10.1172/JCI32691,
May 2008 |
| 12 May |
Dr George van der Watt |
|
| 19 May |
Prof Daan Steenkamp |
"AGE, RAGE and Glyoxalase"
The articles will be various, but the main one will be:
Shin-ichi Sato et al (2007),†Polyproline-Rod Approach to Isolating
Protein Targets of Bioactive Small Molecules: Isolation of a New Target
of Indomethacin. JACS 129,873 - 880. |
| 26 May |
Dr Carel Haumann |
"A translocation causing increased alpha-Klotho level results in hypophosphatemic rickets and hyperparathyroidism"
Proc Nat Acad Sci March 4 2008 vol 105 no 9 pages 3455-3460 |
| 02 Jun |
Dr Peter Berman |
Two recent papers from Nature:
1. Pyruvate kinase M2 is a phosphotyrosine binding protein.
2. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription co-activator. |
| 23 Jun |
Dr John Stanfliet |
Clinical Features and New Molecular Findings in Carnitine Palmitoyltransferase II (CPT II) Deficiency S. Corti, A. Bordoni, D. Ronchi, O. Musumeci, M. Aguennouz,A. Toscano, C. Lamperti, N. Bresolin, G.P. Comi Journal of the Neurological Sciences 266:(2008):97–103 |
| 30 Jun |
Prof David McIntosh |
"The origins of apoptosis"
The take off point is a commentary in Nature 28 May 2008 called Marine Microbiology: Origins of Death. |
| 07 Jul |
Dr Fierdoz Omar |
Low-Intensity Exercise Exerts Beneficial Effects on Plasma Lipids via
PPAR gamma.
Butcher et al.
Med. Sci. Sports Exerc., Vol. 40, No.7, pp 1264-1271, 2008 |
| 04 Aug |
Dr Ryan Benjamin |
"The functional genomics of SCHAD" |
| 18 Aug |
Dr Ryan Benjamin |
Adult IMDs - a compilation of multiple review articles. |
| 25 Aug |
Dr John Stanfliet |
Identification of Pharmacological Chaperones as Potential Therapeutic Agents to Treat Phenylketonuria
J. Clin. Invest. (2008):118;8:1-10
Angel L. Pey, Ming Ying, Nunilo Cremades, Adrian Velazquez-Campoy,Tanja Scherer Beat Thöny, Javier Sancho, and Aurora Martinez. |
| 15 Sep |
Dr David Haarburger |
|
| 22 Sep |
Dr George van der Watt |
|
| 29 Sep |
Prof Howard Henderson |
|
| 06 Oct |
Dr David Haarburger |
|
| 13 Oct |
Dr Khati
CSIR |
"Aptamers: a new frontier in therapeutics and diagnostics" |
| 20 Oct |
Dr John Stanfliet |
Brain-Derived Neurotrophic Factor and Obesity in the WAGR Syndrome
N Engl J Med 2008;359(9):918-927 Joan C. Han et al. |
| 27 Oct |
Dr Ryan Benjamin |
The perils of evidence based medicine.
3 articles from NEJM |
| 03 Nov |
Dr Pete Berman |
"PRDM16 controls a brown fat/skeletal muscle switch"
Seale et al
Nature 21 Aug 2008;454:961-967 |
| 10 Nov |
Prof Daan Steenkamp |
"The Isoniazid Controversy" |
| 17 Nov |
Dr David Haarburger |
|
| 01 Dec |
Dr John Stanfliet |
Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial.
Lancet 2008; 372: 1746-55
Näntö-Salonen K et al. |
Journal Clubs for 2007
| Date (2007) |
Speaker |
Topic |
| 06 Aug |
Dr Carel Haumann |
"Molecular Regulation of HDL Metabolism and Function: Implications for Novel Therapies"
Rader, DJ et al. Journal of Clinical Investigation 116: 3090-3100 (2006) |
| 13 Aug |
Wan Ismail
PhD student |
Thesis Topic"
Jigsaw Puzzle in Understanding the Molecular Basis for Insulin Resistance and Lipodystrophy Induced by HPIs" |
| 20 Aug |
Dr George van der Watt |
"Endocrine Regulation of Energy Metabolism by The Skeleton"
Cell 130, 456 - 469, August 10 2007. |
| 27 Aug |
Prof David McIntosh |
"Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease."
Sever et al, J Clin Invest 2007 Aug 1;117(8):2095-2104 |
| 03 Sep |
Fierdoz Omar |
"Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)"
Peyssonnaux C, Zinkernagel AS, Schuepbach A et al.
Journal of Clinical Investigation 2007; 117(7):1926-1932 |
| 11 Sep |
Prof Daan Steenkamp |
"Applications of Gateway Cloning to Functional Genomics" |
| 17 Sep |
Dr David Haarburger |
"Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia"
Journal of Clinical Investigation Vol 117 Number 8 August 2007 |
| 01 Oct |
Dr Peter Berman |
1. "CD38 is critical for social behavior by regulating oxytocin secretion."
Jin et al. Nature 1 March 2007
2. "Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum."
Painter et al. Nature 1 March 2007
3. "Brain IRS2 signaling coordinates lifespan and nutrient homeostasis."
Taguchi et al. Science 20 July 2007 |
| 08 Oct |
Dr Vuyokazi November |
"Hypoglycaemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase."
J Clin Invest 117, Issue No 4, April 2007 |
| 15 Oct |
Dr Ryan Benjamin |
"The evolving biology and treatment of prostate cancer"
Taichman, Loberg, Mehra, Pienta
Journal of Clinical Investigation 117(9) 2351-2360 |
| 22 Oct |
Dr Carel Haumann |
"Foxo3 is required for the regulation of oxidative stress in erythropoiesis"
Marinkovic et al.
Journal of Clinical Investigation, Volume 117: 8 August 2007 |
| 29 Oct |
Prof Howard Henderson |
1. Mitochondrial dynamics in disease
2. Hold that order for the new thermocycler
3. Muscle cell injury in DMD |
| 05 Nov |
Dr Fierdoz Omar |
"Dose-Dependent Effects of Alcohol on Insulin Signaling: Partial Explanation for Biphasic Alcohol Impact on Human Health."
He L et al.
Molecular Endocrinology 21 (10): 2541-2550 |
| 12 Nov |
Dr George van der Watt |
|
| 19 Nov |
Dr David Haarburger |
|
| 26 Nov |
Dr Maria Berggard-Silow
University of Lund, Sweden |
"Arsenic resistance in Bacillus subtilis" |
|
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