JOURNAL CLUB

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CHEMICAL PATHOLOGY JOURNAL CLUB - FORTHCOMING PRESENTATIONS

The Journal Club on Monday, 13 February 2012 at 11h45
will be presented by Dr John Stanfliet

Topic:
The Athlete Biological Passport
Sottas P et al
Clin Chem 57:7:969-76 (2011)

Venue:
Conference Room 6.22 on level 6 in Division of Chemical Pathology, Falmouth Bdg

All welcome

 

Journal Clubs for 2012 »

Date (2012) Speaker Topic
06 Feb Dave Oxidized high-density lipoprotein as a risk factor for cardiovascular events in prevalent hemodialysis patients
Hirokazu Hondaa et al
Atherosclerosis 220 (2012) 493– 501
13 Feb John

 

20 Feb Nalene  
27 Feb Celeste  
05 Mar ETHICS: Narda  
12 Mar Fierdoz  
19 Mar ETHICS: Laurain  
26 Mar George  
02 Apr Chilu  
09 Apr HOLIDAY  
16 Apr David  
23 Apr Philip  
30 Apr Pete  
07 May Nalene  
14 May Celeste  
21 May Niemand  
28 May Hendre  
04 Jun Dave   
11 Jun Chilu  
18 Jun Fierdoz  
25 Jun Philip  
02 Jul George  
09 Jul VACATION  
16 Jul VACATION  
23 Jul ETHICS  
30 Jul David  
06 Aug Chilu  
13 Aug Nalene  
20 Aug Celeste  
27 Aug Niemand  
03 Sep PATH CONGRESS  
10 Sep Hendre  
17 Sep Dave  
24 Sep HOLIDAY  
01 Oct Philip  
08 Oct Fierdoz  
15 Oct George  
22 Oct Chilu  
29 Oct Celeste  
05 Nov David  
12 Nov Niemand  
19 Nov Hendre  
26 Nov Philip  

 

 

ARCHIVES

Journal Clubs for 2011

Date (2011) Speaker Topic
31 Jan Sumbukeni Persistently Increased Acetaminophen Concentrations in a Patient with Acute Liver Failure.
Fong et al.
Clinical Chemistry 57:1 (2011).
07 Feb John Enhanced Weight Loss with Pramlintide/Metreleptin: An Integrated Neurohormonal Approach to Obesity Pharmacotherapy.
Ravussin et al.
Obesity 17: 1736–1743 (2009)
14 Feb Chilu van Deventer et al. Inverse Log Linear Relationship between Thyroid Stimulating Hormone and Free Thyroxine Measured by Direct Analog Immunoassay and Tandem Mass Spectrometry
Clin Chem 57:1,122-127(2011)
21 Feb David In Vivo Activity of the Thyroid Hormone Receptor beta- and alpha-Selective Agonists GC-24 and CO23 on Rat Liver, Heart, and Brain
Endocrinology, March 2011, 152(3)

A New Small-Molecule Antagonist Inhibits Graves’ Disease Antibody Activation of the TSH Receptor
J Clin Endocrinol Metab 96:548–554, 2011

Thyronamines—Past, Present, and Future
Endocrine Reviews 32: 64–80, 2011

28 Feb George  
07 Mar Ryan  
14 Mar CANCELLED  
21 Mar HOLIDAY  
28 Mar David FGF19 as a Postprandial Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
Science 331(4):1621 (2011 Mar)
04 Apr John  
11 Apr Nolwazi Urinary Catalytic Iron in Obesity
Tina K. Thethi et al.
Clinical Chemistry
57:272-278 (2011)
18 Apr Fierdoz Hepcidin and Thalassaemia
25 Apr HOLIDAY  
02 May HOLIDAY  
09 May Ryan  
16 May Pete Adiponectin and adipoR1 regulate PGC-1a and mitochondria by Ca2+ and AMPK/SIRT1
Iwabu et al
Nature 29 April 2010 pp 1313-1319
23 May Philip  
30 May Ryan Perilipin deficiency and autosomal dominant partial lipodystrophy
Gandotra et al.
NEJM
2011: 364(8): 740-748
06 Jun George  
13 Jun Pete  
20 Jun Fierdoz/Philip Report-back on the recent IFCC meeting they attended in Berlin.
27 Jun Nolwazi Serum concentrations of retinol-binding protein 4 in women with and without gestational diabetes
Diabetologia 51:1115-1122 (2008)
Krzyzanowska, K et al.
04 Jul Carel Carel reported back on the congress he recently attended and presented at in Cardiff, Wales. The topic was "Porphyria".
11 Jul Ify Evaluation of salivary melatonin measurements for Dim Light Melatonin Onset calculations in patients with possible sleep-wake rhythm disorders
Clin Chim Acta 412: 1616 (2011)
18 Jul Fierdoz  
25 Jul John  
01 Aug Carel

Incremental value of HS TropT for risk prediction in patients with suspected AMI
Clin Chem 57:9 (2011)

A national survey of interpretive reporting in the UK
ACB 48:317-320 (2011)

08 Aug CANCELLED  
15 Aug Nalene Preanalytical quality improvement: from dream to reality
Lippi et al
Clinical Chemistry in Laboratory Medicine 49(7):1113-1126 (2011)
22 Aug Philip Mutations in CYP24A1 and Idiopathic Infantile Hypercalcemia
Schlingmann, K. et al.
NEJM 365(5)(2011)
29 Aug CANCELLED  
05 Sep PATH CONGRESS  
12 Sep Chilu Cosmo et al., Mice deficient in mct-8 reveal a mechanism regulating thyroid hormone secretion.
J.Clin.Invest. 2010, 120 (10).
19 Sep Ify Serum hepcidin-25 in comparison to biochemical markers and haematological indices for the differentiation of iron-restricted erythropoiesis
Clin Chem Lab Med 2011;49(2):207-213
26 Sep Chilu Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells
Lukasova M. et al.
J. Clin. Invest. 2011;121(3):1163-1173
03 Oct George  
10 Oct Nalene Streichert et al.
Determination of Hemolysis Thresholds by the Use of Data Loggers in Pneumatic Tube Systems
Clinical Chemistry 57:10,1390-1397(2011)
17 Oct Carel Novel Loss-of-Function PCSK9 Variant Is Associated with Low Plasma LDL Cholesterol in a French-Canadian Family and with Impaired Processing and Secretion in Cell Culture. Mayne J, Dewpura T, Raymond A, Bernier L, Cousins M, Ooi TC, Davignon J, Seidah NG, Mbikay M, Chrétien M.
Clin Chem. 2011 Oct;57(10):1415-23
24 Oct David

Relationship between Urinary Bisphenol A Levels and Diabetes Mellitus
J Clin Endocrinol Metab 96(12) (2011)

Urinary Bisphenol A and Obesity
Environ Res 111(6):825-30 (2011

31 Oct Chilu ProBNP 1-108 is Resistant to Degradation and Activates Guanylyl Cyclase-A with Reduced Potency
Dickey D and Potter L
Clin Chem 57(9): 1272-1278 (2011)
07 Nov Philip Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor.
Brothers et al
Cell metabolism
12: 295-305 (2010)
14 Nov Ryan  
21 Nov Pete

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR-gamma by Cdk5
Choi et al
Nature 22 July 2010

28 Nov John Rapid and Specific Quantification of Ethylene Glycol Levels - Adaptation of a Commercial Enzymatic Assay to Automated Chemistry Analyzers
Juenke et al.
Am J Clin Pathol 2011;136:318-324

 

Journal Clubs for 2010

Date (2010) Speaker Topic
01 Feb Pete Various topics including:
'brown adipose tissue' (New England Journal of Medicine, April 2009)
'Regulation of adaptive behaviour during fasting by hypothalamic Foxa2' (Nature, 3 Dec 2009)
08 Feb Fierdoz Barnes AM et al. Lack of Cyclophilin B in osteogenesis imperfecta with normal collagen folding. NEJM 2010 (online ahead of publication)
15 Feb Ryan TBA
22 Feb George Rosengren AH, Jokubka R, Tojjar D, et al. Overexpression of the alpha2A‑adrenergic receptors contributes to type2 diabetes.
Science, 8 Jan, 2010, (327)
01 Mar John Rebecca W.Y. Chan, John Wong, Henry L.Y. Chan, Tony S.K. Mok, Wyatt Y.W. Lo, Vincent Lee, Ka F. To, Paul B.S. Lai, Timothy H. Rainer, Y.M. Dennis Lo, and Rossa W.K. Chiu.
Aberrant concentrations of liver‑derived plasma albumin mRNA in liver pathologies.
Clin Chem 56:1:82‑89 (2010)
08 Mar David Leptin therapy in insulin‑deficient type I diabetes
From PNAS published ahead of print
15 Mar Sumbukeni Assessment of Vitamin B12 Absorption Based on the Accumulation of Orally Administered Cyanocobalamin on Transcobalamin.
Hardlei et al.
Clinical Chemistry
56(3):432‑436 (2010)
22 Mar HOLIDAY  
29 Mar Philip  
05 Apr HOLIDAY  
12 Apr Chilu Ischaemia‑modified albumin elevation after percutaneous coronary intervention reflects albumin concentration rather than ischaemia.
Annals of Clinical Biochemistry 46 (4): 327‑331 (2009)
Demir, H et al
19 Apr Philip Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice
J Clin Invest 120 (4), April 2010
26 Apr HOLIDAY(27th)  
03 May Ryan Renal tubular acidosis with two unusual case reports
Singapore Med Case Report J 2010; 51(2) : e24
Indian Pediatr 2009;46: 532‑534
10 May Chilu High‑sensitivity cardiac troponin T for early prediction of evolving non‑ST segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission.
Giannitsis et al
Clin Chem 56(4): 642‑650
17 May Sumbukeni Zinc Supplementation Improves the Outcome of Chronic Hepatitis C and Liver Cirrhosis
M. Moriyama et al
J. Clin. Biochem. Nutr., 45, 292-303, November 2009
24 May David Presentation of his MMed thesis:
"Serum proteome changes after HIV infection"
31 May John Report back on highlights of the recent Association of Clinical Biochemists (ACB) Focus 2010 Congress in Glasgow (10‑13 May 2010)
07 Jun Chilu Urinary proteases degrade albumin: implications for measurement of albuminuria in stored samples
Kania et al
Annals of Clinical Biochemistry 47:151‑157 (2010)
14 Jun David Ghrelin O-acyltransferase is essential for growth hormone-mediated survival of calorie-restricted mice
21 Jun Philip Case studies in calcium and phosphate metabolism
28 Jun Ryan Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation
Bermans J et al
J Clin Invest 2010;120(5):1603–1616
05 Jul John Seven Direct Methods for Measuring HDL and LDL Cholesterol Compared with Ultracentrifugation Reference Measurement Procedures
Miller, WG et al
Clinical Chemistry 56:6:977–986 (2010)
12 Jul CANCELLED  
19 Jul Fierdoz MMed research project:
Investigation of High Molecular Weight Adiponectin in HIV‑Infected Patients on Antiretroviral Therapy
26 Jul George MMed research project:
Mitochondrial DNA ratios in HIV‑positive children
02 Aug Sumbukeni Efficacy and safety of exenatide once weekly as an adjunct to metformin for the treatment of type‑2 diabetes" (DURATION 2) : A randomised trial
Lancet online version of 26/06/2010
09 Aug HOLIDAY  
16 Aug Chilu Hedgehog signaling has a protective effect in glucocorticoid‑induced mouse neonatal brain injury through an 11βHSD2‑dependent mechanism
Heine and Rowitch
J Clin Invest 119(2):267‑277 (2009)
23 Aug Pete

1. Amino acid imbalance explains extension of lifespan by dietary restriction in Drosophila   Nature 31 December 2009

2. A cognitively normal PDH‑deficient 18 year old man carrying the R263G mutation in the PDHA1 gene  J. Inherit. Metab. Dis. 31 July 2009

30 Aug Philip Persistent increase of cardiac troponin I in plasma without evidence of cardiac injury
Clin. Chem. 56: 702‑707 (2010)
06 Sep PATH CONGRESS  
13 Sep Ryan  
20 Sep John Vitreous Humor: Biochemical Constituents in Estimation of Postmortem Interval
Jashnani KD, Kale SA & Rupani AB
J Forensic Sci 2010 July 28 [epub ahead of print]
27 Sep George

Vascular endothelial growth factor B controls endothelial fatty acid uptake
Hagberg et al.
Nature Vol 464, 8 April 2010

The complete mitochondrial DNA genome of an unknown hominid from southern Siberia
Krause et al.
Nature Vol 464, 8 April 2010

04 Oct David Report-back on the AACC 2010 conference in Anaheim, CA
11 Oct Sumbukeni Rethinking the Stalk Effect: A New Hypothesis Explaining Suprasellar Tumour Induced Hyperprolactinemia
Donal C. Skinner
Med Hypotheses March 2009
18 Oct Chilu Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia
Mitchell,Savage et al
Journal of Clinical Investigation 120(4), April 2010
25 Oct Fierdoz  
01 Nov Philip Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study
P Matarrese et al
Molecular Cancer 9:207-221 (2010)
08 Nov CANCELLED  
15 Nov Ian Machingura The Genetic Basis of Nephropathy in Diabetic Patients
22 Nov Ryan

Leigh Syndrome

Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome.
Quintina et al. PNAS 2010 107(24): 10996-11001

Leigh and Leigh-like syndromes in children and adults.
Finsterer. Pediatric neurology 2008 39(4): 223-235

Leigh syndrome: clinical features and biochemical and DNA abnormalities.
Rahman et al. Annals of Neurology 1996 39(3): 343-351

Subacute necrotizing encephalomyelopathy in an infant.
Leigh. Journal of neurology, neurosurgery and psychiatry 1951 14: 216-221

6 Dec Pete

1. Biochemical abnormalities in a patient with thymidine phosphorylase deficiency with fatal outcome.
Bakker et al,
J Inherit. Metab. Dis. 2010

2. Molecular mechanisms of mtDNA depletion diseases caused by deficiencies in enzymes in purine and pyrimidine metabolism. Eriksson & Wang,
Nucleosides, Nucleotides & Nucleic acids. 27:800 2008

3. Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mtDNA depletion. Bourdon et al
Nature Genetics 39:776 2007

4. Mutant mitochondrial thymidine kinase in mtDNA depletion myopathy. Saada et al
Nature Genetics 29:342 2001

5. The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mtDNA. Mandel et al
Nature Genetics 29:337 2001

6. PGC-1alpha, a potential therapeutic target for early intervention in Parkinson's Disease. Zeng et al.
Sci. Transl. Med. 2010

 

Journal Clubs for 2009

Date (2009) Speaker Topic
02 Feb Dr David Haarburger "Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse"
09 Feb Dr Ryan Benjamin "The value of measurement of cystatin C in renal disease"
16 Feb Prof TS Pillay "Please, SIR(T), may I have some more!.....Calorie restriction, aging, antioxidants and transcriptional regulation"
23 Feb Dr John Stanfliet Standardization of High-Sensitivity Immunoassays for Measurement of C-Reactive Protein: Two Approaches for Assessing Commutability of a Reference Material
Clin Chem(2009)55:2:342-350
Kimberly MM et al.
02 Mar Dr Philip Fortgens Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney
J. Clin. Invest. 118(7):2525-2534 (2008)
09 Mar Dr Peter Berman

1. A receptor that mediates the post-mating switch in Drosophila reproductive behaviour.
Yapici et al Nature 3 Jan 2008

2. A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility.
Biver et al Nature 20 Nov 2008

3. The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes.
Graves et al Nature 5 June 2008

4. Structural basis for androgen specificity and oestrogen synthesis in human aromatase.
Ghosh et al Nature 8 Jan 2009

16 Mar Dr Vuyo Keti Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction Via AMPK-eNOS–Mediated Signaling
Diabetes 57:696-705, 2008
23 Mar Dr David Haarburger

Genetically elevated C-reactive protein and ischemic vascular disease
N Engl J Med. 2008 Oct 30;359(18):1897-908.

Clinical practice. Carbon monoxide poisoning
N Engl J Med. 2009 Mar 19;360(12):1217-25

A family with complete resistance to thyrotropin-releasing hormone.
N Engl J Med. 2009 Feb 12;360(7):731-4

An unusual outbreak of hypoglycemia.
N Engl J Med. 2009 Feb 12;360(7):734-6

30 Mar Dr Jim Bonham EQA for IEM testing
06 Apr Dr Chilu Chingwanda Mortality Results from a Randomized Prostate-Cancer Screening Trial
Andriole et al
N Engl J Med 2009;360(13):1310-1319
20 Apr Dr Fierdoz Omar  
04 May Dr George van der Watt Mechanism of age dependent susceptibility and novel treatment strategy in glutaric acidemia type 1
Zinnati et al
J Clin Invest 117(11):3258-70
11 May Dr John Stanfliet Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis.
Galluzzo et al.
J Clin Invest (2009):119;4:865-875
18 May Dr Philip Fortgens B-Type Natriuretic Peptide Testing, Clinical Outcomes, and Health Services Use in Emergency Department Patients With Dyspnea: A Randomized Trial
Ann Intern Med. 2009;150:365-371
25 May Dr Vuyo Keti Genetic polymorphisms of the natriuretic peptide system in the pathogenesis of cardiovascular disease
Clin Chem 55:878-887, 2009
01 Jun Prof TS Pillay

Protein phosphorylation and biochemical disease: selected examples.

"Nudge-Nudge; Wnk Wnk :)""A Hard Akt to follow "
Electrolyte regulation and hypertension
Biochem. J. (2004) 378, 257–268 ,257

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate
J Clin Invest. 2007 April 2; 117(4): 1078–1087.

Intersectin links WNK kinases to endocytosis of ROMK1
Science 2004 May 28 304(5675) 1325-1328

A Family with Severe Insulin Resistance and Diabetes Mellitus due to a Missense Mutation in AKT2

08 Jun Prof Howard Henderson mDNA sequencing, metabolomics in prostate cancer, autophagy in fat metabolism and endothelial lipase.
22 Jun Dr Ryan Benjamin Thyroid hormones act indirectly to increase sex-hormone-binding globulin production by liver via hepatocyte nuclear factor 4 alpha.
Selva and Hammond
Journal of Molecular Endocrinology (July 2009, pre-print)
29 Jun Dr John Stanfliet Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials.
K K Ray et al.
Lancet 2009;373:1765-72
06 Jul Dr David Haarburger Unbound (Free) Bilirubin: Improving the Paradigm for Evaluating Neonatal Jaundice
Clinical Chemistry 55:7 1288-1299 (2009)
13 Jul Dr Chilu Chingwanda Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.
Stanhope, Schwarz et al.
J Clin Invest 119(5): 1322-1334 (2009)
20 Jul Dr Pete Berman 1. Ethanol acutely stimulates islet blood flow, amplifies insulin secretion and induces hypoglycaemia via nitric oxide and vagally mediated mechanisms.
Huang et al. Endocrinology 2008
2. Mammalian sirtuins- emerging roles in physiology, aging and calorie restriction.
Haigis et al. Genes and development 2006
27 Jul Dr Vuyo Keti Type 2 Iodothyronine Deiodinase in Skeletal Muscle: Effects of Hypothyroidism and Fasting.
Karen et al.
J Clin Endocrinol Metab 2009 94: 2144-2150
03 Aug Dr Philip Fortgens Can licorice lick colon cancer?
J Clin Invest (2009) 119(4): 760-763 and 876-885
17 Aug Dr Ryan Benjamin  
24 Aug Dr John Stanfliet Antibodies against synthetic deamidated gliadin peptides for celiac disease diagnosis and follow-up in children.
Daniela Basso et al.
Clin Chem 55:150-7 (January 2009)
31 Aug Dr Fierdoz Omar  
14 Sep Dr George van der Watt

Tumours with PI3K activation are resistant to dietary restriction.

The authors show that mouse or human tumours in which the PI3K/Akt pathway is constitutively activated are resistant to dietary restriction whereas other tumours are sensitive. The authors also implicate the Akt target gene FOXO1 in the response to dietary restriction.

Nada Y. Kalaany & David M. Sabatini
Nature 458, 725-731 (9 April 2009)

21 Sep Dr Philip Fortgens Dissociation of Pentameric to Monomeric C-Reactive Protein on Activated Platelets Localizes Inflammation to Atherosclerotic Plaques. Steffen U. Eisenhardt et al.
Circulation Res. 105:128-137 (2009)
28 Sep Dr Chilu Chingwanda Circulating calcitriol concentrations and total mortality.
Zitterman et al.
Clinical Chemistry 55;1163-1170,2009
05 Oct Prof TS Pillay

1) The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts
J Clin Invest September 2009

2) Mitochondrial gene replacement in primate offspring and embryonic stem cells
Nature September 2009

12 Oct Dr Ryan Benjamin Serum free light chain assay reduces the need for serum and urine immunofixation electrophoresis in the evaluation of monoclonal gammopathy
Fulton and Fernando
ACB 2009 46:407-412

Serum free light chain analysis may miss monoclonal light chain disease that urine immunofixation may detect
Shaheen and Levinson
Clinica Chimica Acta 2009 406:162-166

26 Oct Dr Vuyo Keti Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I
J. Clin. Invest.119(9): 2737-2744 (September 1,2009)
02 Nov Prof Howard Henderson AIDS, autophagy, endothelial lipase and "call back the past"
09 Nov Dr Fierdoz Omar A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus.
The Journal of Clinical Investigation Volume 119 Number 10 October 2009
16 Nov Dr Pete Berman  
23 Nov Dr John Stanfliet Differences in Recognition of the 1st WHO International Reference Reagents for hCG-Related Isoforms by Diagnostic Immunoassays for Human Chorionic Gonadotropin
Sturgeon CM, Berger P, Bidart J, Birken S, Burns C, Norman R and Stenman U
Clinical Chemistry (2009) 55:8:1484-1491
30 Nov Dr David Haarburger Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X‑Linked Adrenoleukodystrophy
Science 326, 818 (6 November 2009)

Journal Clubs for 2008

Date (2008) Speaker Topic
04 Feb Dr Carel Haumann "Diagnosis of alpha-1-antitrypsin deficiency: an algorithm of quantification, genotyping and phenotyping"
Clin Chem 52:12: 2236-2242 (2006)
11 Feb Dr Vuyokazi November Capellini MD, Fiorelli G
"Glucose-6-phosphate dehydrogenase deficiency"
Lancet 371:64-74 (2008)
18 Feb Dr Pete Berman

1. Co-operation and conflict in quorum-sensing bacterial populations.

2. Phagocyte-derived catecholamines enhance acute inflammatory injury.

3. p53 regulates maternal reproduction through LIF.

All articles are from recent editions of Nature.

25 Feb Dr Ryan Benjamin "Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage." Muniyappa, Lee, Chen, Quon
Am J Physiol Endo Metab 294:E15-E26 (2008)
03 Mar Dr Carel Haumann "Reactivity of Urinary Albumin (Microalbumin) Assays with Fragmented or Modified Albumin."
Clinical Chemistry 2008 54:1 61-68
10 Mar Dr Fierdoz Omar "Metabolomics Identifies Perturbations in Human Disorders of Propionate Metabolism"
Wikoff WR et al.
Clinical Chemistry 2007:53(12); 2169
31 Mar Dr John Stanfliet "Iron stores, blood donation and insulin sensitivity and secretion"
Journal of Clinical Chemistry 51: 1201-1205 (2005)
07 Apr Prof Howard Henderson Neuronal fireworks
TLR-polymorphisms
SNP associations
14 Apr Dr David Haarburger Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia.
PNAS
105: 4242-4246 (March 2008)
21 Apr Dr Ryan Benjamin 3-D cellular microarray for high-throughput toxicology assays.
PNAS 105: 59--63 (Jan 2008)
05 May Dr Fierdoz Omar Adiponectin regulates albuminuria and podocyte function in mice. Sharma et al,
J Clin Invest doi:10.1172/JCI32691, May 2008
12 May Dr George van der Watt  
19 May Prof Daan Steenkamp "AGE, RAGE and Glyoxalase"
The articles will be various, but the main one will be:
Shin-ichi Sato et al (2007),†Polyproline-Rod Approach to Isolating
Protein Targets of Bioactive Small Molecules: Isolation of a New Target
of Indomethacin. JACS 129,873 - 880.
26 May Dr Carel Haumann "A translocation causing increased alpha-Klotho level results in hypophosphatemic rickets and hyperparathyroidism"
Proc Nat Acad Sci March 4 2008 vol 105 no 9 pages 3455-3460
02 Jun Dr Peter Berman

Two recent papers from Nature:

1. Pyruvate kinase M2 is a phosphotyrosine binding protein.

2. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription co-activator.

23 Jun Dr John Stanfliet Clinical Features and New Molecular Findings in Carnitine Palmitoyltransferase II (CPT II) Deficiency S. Corti, A. Bordoni, D. Ronchi, O. Musumeci, M. Aguennouz,A. Toscano, C. Lamperti, N. Bresolin, G.P. Comi Journal of the Neurological Sciences 266:(2008):97–103
30 Jun Prof David McIntosh

"The origins of apoptosis"
The take off point is a commentary in Nature 28 May 2008 called Marine Microbiology: Origins of Death.

07 Jul Dr Fierdoz Omar Low-Intensity Exercise Exerts Beneficial Effects on Plasma Lipids via PPAR gamma. Butcher et al.
Med. Sci. Sports Exerc., Vol. 40, No.7, pp 1264-1271, 2008
04 Aug Dr Ryan Benjamin "The functional genomics of SCHAD"
18 Aug Dr Ryan Benjamin Adult IMDs - a compilation of multiple review articles.
25 Aug Dr John Stanfliet Identification of Pharmacological Chaperones as Potential Therapeutic Agents to Treat Phenylketonuria
J. Clin. Invest. (2008):118;8:1-10
Angel L. Pey, Ming Ying, Nunilo Cremades, Adrian Velazquez-Campoy,Tanja Scherer Beat Thöny, Javier Sancho, and Aurora Martinez.
15 Sep Dr David Haarburger  
22 Sep Dr George van der Watt  
29 Sep Prof Howard Henderson  
06 Oct Dr David Haarburger  
13 Oct Dr Khati
CSIR
"Aptamers: a new frontier in therapeutics and diagnostics"
20 Oct Dr John Stanfliet Brain-Derived Neurotrophic Factor and Obesity in the WAGR Syndrome
N Engl J Med 2008;359(9):918-927 Joan C. Han et al.
27 Oct Dr Ryan Benjamin The perils of evidence based medicine.
3 articles from NEJM
03 Nov Dr Pete Berman "PRDM16 controls a brown fat/skeletal muscle switch"
Seale et al
Nature 21 Aug 2008;454:961-967
10 Nov Prof Daan Steenkamp "The Isoniazid Controversy"
17 Nov Dr David Haarburger  
01 Dec Dr John Stanfliet Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial.
Lancet 2008; 372: 1746-55
Näntö-Salonen K et al.

 

Journal Clubs for 2007

Date (2007) Speaker Topic
06 Aug Dr Carel Haumann "Molecular Regulation of HDL Metabolism and Function: Implications for Novel Therapies"
Rader, DJ et al. Journal of Clinical Investigation 116: 3090-3100 (2006)
13 Aug Wan Ismail
PhD student
Thesis Topic"
Jigsaw Puzzle in Understanding the Molecular Basis for Insulin Resistance and Lipodystrophy Induced by HPIs"
20 Aug Dr George van der Watt "Endocrine Regulation of Energy Metabolism by The Skeleton"
Cell 130, 456 - 469, August 10 2007.
27 Aug Prof David McIntosh "Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease."
Sever et al, J Clin Invest 2007 Aug 1;117(8):2095-2104
03 Sep Fierdoz Omar "Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)"
Peyssonnaux C, Zinkernagel AS, Schuepbach A et al.
Journal of Clinical Investigation 2007; 117(7):1926-1932
11 Sep Prof Daan Steenkamp "Applications of Gateway Cloning to Functional Genomics"
17 Sep Dr David Haarburger "Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia"
Journal of Clinical Investigation Vol 117 Number 8 August 2007
01 Oct Dr Peter Berman

1. "CD38 is critical for social behavior by regulating oxytocin secretion."
Jin et al. Nature 1 March 2007

2. "Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum."
Painter et al. Nature 1 March 2007

3. "Brain IRS2 signaling coordinates lifespan and nutrient homeostasis."
Taguchi et al. Science 20 July 2007

08 Oct Dr Vuyokazi November "Hypoglycaemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase."
J Clin Invest
117, Issue No 4, April 2007
15 Oct Dr Ryan Benjamin "The evolving biology and treatment of prostate cancer"
Taichman, Loberg, Mehra, Pienta
Journal of Clinical Investigation
117(9) 2351-2360
22 Oct Dr Carel Haumann "Foxo3 is required for the regulation of oxidative stress in erythropoiesis"
Marinkovic et al.
Journal of Clinical Investigation, Volume 117: 8 August 2007
29 Oct Prof Howard Henderson 1. Mitochondrial dynamics in disease

2. Hold that order for the new thermocycler

3. Muscle cell injury in DMD

05 Nov Dr Fierdoz Omar "Dose-Dependent Effects of Alcohol on Insulin Signaling: Partial Explanation for Biphasic Alcohol Impact on Human Health."
He L et al.
Molecular Endocrinology 21 (10): 2541-2550
12 Nov Dr George van der Watt  
19 Nov Dr David Haarburger  
26 Nov Dr Maria Berggard-Silow
University of Lund, Sweden
"Arsenic resistance in Bacillus subtilis"

 


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